2rt5

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m (Protected "2rt5" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_2rt5| PDB=2rt5 | SCENE= }}
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===Structural insights into the recruitment of SMRT by the co-repressor SHARP under phosphorylative regulation===
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{{ABSTRACT_PUBMED_24268649}}
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The entry 2rt5 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/MINT_HUMAN MINT_HUMAN]] May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.<ref>PMID:11331609</ref> <ref>PMID:12374742</ref> [[http://www.uniprot.org/uniprot/NCOR2_HUMAN NCOR2_HUMAN]] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.
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Authors: Mikami, S., Kanaba, T., Mishima, M.
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==About this Structure==
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[[2rt5]] is a 2 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RT5 OCA].
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Description: Structural insights into the recruitment of SMRT by the co-repressor SHARP under phosphorylative regulation
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==Reference==
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<ref group="xtra">PMID:024268649</ref><references group="xtra"/><references/>
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[[Category: Kanaba, T.]]
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[[Category: Mikami, S.]]
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[[Category: Mishima, M.]]
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[[Category: Phosphorylation]]
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[[Category: Sharp]]
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[[Category: Smrt]]
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[[Category: Spoc domain]]
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[[Category: Transcription regulator]]

Revision as of 07:20, 4 December 2013

Template:STRUCTURE 2rt5

Contents

Structural insights into the recruitment of SMRT by the co-repressor SHARP under phosphorylative regulation

Template:ABSTRACT PUBMED 24268649

Function

[MINT_HUMAN] May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.[1] [2] [NCOR2_HUMAN] Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.

About this Structure

2rt5 is a 2 chain structure. Full experimental information is available from OCA.

Reference

  • Mikami S, Kanaba T, Takizawa N, Kobayashi A, Maesaki R, Fujiwara T, Ito Y, Mishima M. Structural Insights into the Recruitment of SMRT by the Corepressor SHARP under Phosphorylative Regulation. Structure. 2013 Nov 19. pii: S0969-2126(13)00400-0. doi:, 10.1016/j.str.2013.10.007. PMID:24268649 doi:http://dx.doi.org/10.1016/j.str.2013.10.007
  1. ↑ Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM. Sharp, an inducible cofactor that integrates nuclear receptor repression and activation. Genes Dev. 2001 May 1;15(9):1140-51. PMID:11331609 doi:http://dx.doi.org/10.1101/gad.871201
  2. ↑ Oswald F, Kostezka U, Astrahantseff K, Bourteele S, Dillinger K, Zechner U, Ludwig L, Wilda M, Hameister H, Knochel W, Liptay S, Schmid RM. SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway. EMBO J. 2002 Oct 15;21(20):5417-26. PMID:12374742

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