4cb8

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m (Protected "4cb8" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4cb8| PDB=4cb8 | SCENE= }}
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===Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha===
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{{ABSTRACT_PUBMED_24269683}}
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The entry 4cb8 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CTBL1_HUMAN CTBL1_HUMAN]] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.<ref>PMID:12659813</ref> <ref>PMID:18722174</ref>
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Authors: Ganesh, K., vanMaldegem, F., Telerman, S.B., Simpson, P., Johnson, C.M., Williams, R.L., Neuberger, M.S., Rada, C.
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==About this Structure==
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[[4cb8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CB8 OCA].
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Description: Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha
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==Reference==
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<ref group="xtra">PMID:024269683</ref><references group="xtra"/><references/>
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[[Category: Ganesh, K.]]
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[[Category: Johnson, C M.]]
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[[Category: Neuberger, M S.]]
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[[Category: Rada, C.]]
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[[Category: Simpson, P.]]
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[[Category: Telerman, S B.]]
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[[Category: Williams, R L.]]
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[[Category: VanMaldegem, F.]]
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[[Category: Aid]]
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[[Category: Apoptosis]]
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[[Category: Deaminase]]
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[[Category: Import]]

Revision as of 07:21, 4 December 2013

Template:STRUCTURE 4cb8

Contents

Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha

Template:ABSTRACT PUBMED 24269683

Function

[CTBL1_HUMAN] Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. Participates in AID/AICDA-mediated Ig class switching recombination (CSR). May induce apoptosis.[1] [2]

About this Structure

4cb8 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Ganesh K, van Maldegem F, Telerman SB, Simpson P, Johnson CM, Williams RL, Neuberger MS, Rada C. Structural and mutational analysis reveals that CTNNBL1 binds NLSs in a manner distinct from that of its closest armadillo-relative, karyopherin alpha FEBS Lett. 2013 Nov 20. pii: S0014-5793(13)00847-8. doi:, 10.1016/j.febslet.2013.11.013. PMID:24269683 doi:http://dx.doi.org/10.1016/j.febslet.2013.11.013
  1. ↑ Jabbour L, Welter JF, Kollar J, Hering TM. Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis. Genomics. 2003 Mar;81(3):292-303. PMID:12659813
  2. ↑ Conticello SG, Ganesh K, Xue K, Lu M, Rada C, Neuberger MS. Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol Cell. 2008 Aug 22;31(4):474-84. doi: 10.1016/j.molcel.2008.07.009. PMID:18722174 doi:10.1016/j.molcel.2008.07.009

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