2m7q

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'''Unreleased structure'''
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{{STRUCTURE_2m7q| PDB=2m7q | SCENE= }}
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===Solution structure of TAX1BP1 UBZ1+2===
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{{ABSTRACT_PUBMED_24239949}}
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The entry 2m7q is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/TAXB1_HUMAN TAXB1_HUMAN]] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.<ref>PMID:10435631</ref> <ref>PMID:10920205</ref>
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Authors: Ceregido, M., Spinola, M., Buts, L., Bravo, J., van Nuland, N.
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==About this Structure==
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[[2m7q]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M7Q OCA].
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Description: Solution structure of TAX1BP1 UBZ1+2
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==Reference==
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<ref group="xtra">PMID:024239949</ref><references group="xtra"/><references/>
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[[Category: Amilibia, M Spinola.]]
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[[Category: Bravo, J.]]
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[[Category: Buts, L.]]
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[[Category: Ceregido, M A.]]
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[[Category: Nuland, N A.J van.]]
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[[Category: Metal binding protein]]
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[[Category: Tax1bp1]]
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[[Category: Ubd]]
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[[Category: Ubz domain]]
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[[Category: Zinc finger domain]]

Revision as of 07:22, 4 December 2013

Template:STRUCTURE 2m7q

Contents

Solution structure of TAX1BP1 UBZ1+2

Template:ABSTRACT PUBMED 24239949

Function

[TAXB1_HUMAN] Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.[1] [2]

About this Structure

2m7q is a 1 chain structure. Full experimental information is available from OCA.

Reference

  • Ceregido MA, Spinola Amilibia M, Buts L, Rivera-Torres J, Garcia-Pino A, Bravo J, van Nuland NA. The Structure of TAX1BP1 UBZ1+2 Provides Insight into Target Specificity and Adaptability. J Mol Biol. 2013 Nov 13. pii: S0022-2836(13)00717-1. doi:, 10.1016/j.jmb.2013.11.006. PMID:24239949 doi:http://dx.doi.org/10.1016/j.jmb.2013.11.006
  1. ↑ De Valck D, Jin DY, Heyninck K, Van de Craen M, Contreras R, Fiers W, Jeang KT, Beyaert R. The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases. Oncogene. 1999 Jul 22;18(29):4182-90. PMID:10435631 doi:http://dx.doi.org/10.1038/sj.onc.1202787
  2. ↑ Ling L, Goeddel DV. T6BP, a TRAF6-interacting protein involved in IL-1 signaling. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9567-72. PMID:10920205 doi:http://dx.doi.org/10.1073/pnas.170279097

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