4lqd

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'''Unreleased structure'''
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{{STRUCTURE_4lqd| PDB=4lqd | SCENE= }}
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===The crystal structures of the Brucella protein TcpB and the TLR adaptor protein TIRAP show structural differences in microbial TIR mimicry===
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The entry 4lqd is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/TIRAP_HUMAN TIRAP_HUMAN]] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.<ref>PMID:18292575</ref> <ref>PMID:19509286</ref>
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Authors: Snyder, G.A., Smith, P., Jiang, J., Xiao, T.S.
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==About this Structure==
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[[4lqd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LQD OCA].
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Description: The crystal structures of the Brucella protein TcpB and the TLR adaptor protein TIRAP show structural differences in microbial TIR mimicry
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Jiang, J.]]
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[[Category: Smith, P.]]
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[[Category: Snyder, G A.]]
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[[Category: Xiao, T S.]]
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[[Category: Flavodoxin fold]]
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[[Category: Immune system]]
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[[Category: Myd88]]
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[[Category: Toll-like receptor signaling adaptor]]

Revision as of 07:32, 4 December 2013

Template:STRUCTURE 4lqd

Contents

The crystal structures of the Brucella protein TcpB and the TLR adaptor protein TIRAP show structural differences in microbial TIR mimicry

Function

[TIRAP_HUMAN] Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.[1] [2]

About this Structure

4lqd is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Semaan N, Alsaleh G, Gottenberg JE, Wachsmann D, Sibilia J. Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. J Immunol. 2008 Mar 1;180(5):3485-91. PMID:18292575
  2. ↑ Nagpal K, Plantinga TS, Wong J, Monks BG, Gay NJ, Netea MG, Fitzgerald KA, Golenbock DT. A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling. J Biol Chem. 2009 Sep 18;284(38):25742-8. doi: 10.1074/jbc.M109.014886. Epub 2009, Jun 9. PMID:19509286 doi:http://dx.doi.org/10.1074/jbc.M109.014886

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