Hairpin Ribozyme

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 4: Line 4:
Anything in this section will appear adjacent to the 3D structure and will be scrollable.
Anything in this section will appear adjacent to the 3D structure and will be scrollable.
-
The hairpin ribozyme is a member of a small family of RNA endonucleases that includes hammerhead, hepatitis delta, and Neurospora VS. Endonucleases are enzymes that cleave phosphodiester bonds within polynucleotide chains. This group of endonucleases cleave RNA substrates in a reversible reaction that generates a 2', 3'-cyclic phosphate and a 5'-hydroxyl termini.
+
The hairpin ribozyme is a member of a small family of RNA endonucleases that includes hammerhead, hepatitis delta, and Neurospora VS. Endonucleases are enzymes that cleave phosphodiester bonds within polynucleotide chains. This group of endonucleases cleave RNA substrates in a reversible reaction that generates a 2', 3'-cyclic phosphate and a 5'-hydroxyl termini.<ref>PMID: 10715200</ref>
 +
 
The hairpin ribozyme was discovered in the negative strand of the tobacco ringspot virus satellite RNA. Study of hairpin ribozyme reaction mechanisms provided early evidence that ribozymes are able to exploit a variety of strategies, just like protein enzymes. But, the hairpin ribozyme has a unique characteristic. Unlike other ribozymes, the hairpin ribozyme does not require metal ions for cleavage or ligation of substrate RNA.
The hairpin ribozyme was discovered in the negative strand of the tobacco ringspot virus satellite RNA. Study of hairpin ribozyme reaction mechanisms provided early evidence that ribozymes are able to exploit a variety of strategies, just like protein enzymes. But, the hairpin ribozyme has a unique characteristic. Unlike other ribozymes, the hairpin ribozyme does not require metal ions for cleavage or ligation of substrate RNA.
Line 13: Line 14:
==References==
==References==
 +
 +
<references/>

Revision as of 21:21, 4 December 2013

This Sandbox is Reserved from September 14, 2021, through May 31, 2022, for use in the class Introduction to Biochemistry taught by User:John Means at the University of Rio Grande, Rio Grande, OH, USA. This reservation includes 5 reserved sandboxes (Sandbox Reserved 1590 through Sandbox Reserved 1594).
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing. For an example of a student Proteopedia page, please see Photosystem II, Tetanospasmin, or Guanine riboswitch.

Hairpin Ribozyme Overview

Crystal Structure of the Hairpin Ribozyme in the catalytically-active conformation (PDB entry 1m5k)

Drag the structure with the mouse to rotate

Structure

In the transition state, the

References

  1. ↑ Fedor MJ. Structure and function of the hairpin ribozyme. J Mol Biol. 2000 Mar 24;297(2):269-91. PMID:10715200 doi:http://dx.doi.org/10.1006/jmbi.2000.3560

Proteopedia Page Contributors and Editors (what is this?)

Michael Parcell, John Means, Jaime Prilusky, Michal Harel

Retrieved from "http://52.214.119.220/wiki/index.php/Hairpin_Ribozyme"
Personal tools