Pregnane X receptor (PXR) is a nuclear receptor which senses the presence of toxic substances and regulates the expression of proteins which are involved in detoxificaton. PXR is activated by a large range of steroids, antibiotics, bile acids and many herbal compounds. Thus it is a generalized sensor of hydrophobic toxins. When activated, PXR binds to the retinoid X receptor (RXR) and the formed heterodimer binds to hormone response elements on the DNA. PXR, similar to other nuclear receptors contains a ligand-binding domain (LBD) and DNA-binding domain (DBD).
1ilg – hPXR LBD – human
3ctb – hPXR/steroid receptor coactivator
4j5w – hPXR LBD + hRXR LBD
PXR complex with ligand
1ilh, 2qnv – hPXR LBD + ligand
1m13 – hPXR LBD + hyperforin
1skx – hPXR LBD + antibiotic
3r8d – hPXR LBD + anti-HIV drug
1nrl, 2o9i – hPXR LBD + nuclear receptor coactivator peptide + ligand
4j5x – hPXR LBD + hRXR LBD + ligand
3hvl – hPXR/steroid receptor coactivator + ligand
