This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Pregnane X receptor
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
<StructureSection load='1skx' size='350' side='right' caption='Structure of human pregnane X receptor LBD complex with antibiotic rifampicin (PDB entry [[1skx]])' scene=''> | <StructureSection load='1skx' size='350' side='right' caption='Structure of human pregnane X receptor LBD complex with antibiotic rifampicin (PDB entry [[1skx]])' scene=''> | ||
| - | '''Pregnane X receptor''' (PXR) is a | + | '''Pregnane X receptor''' (PXR) is a [[Nuclear receptor]] which senses the presence of toxic substances and regulates the expression of proteins which are involved in detoxificaton. PXR is activated by a large range of steroids, antibiotics, bile acids and many herbal compounds. Thus it is a generalized sensor of hydrophobic toxins. When activated, PXR binds to the retinoid X receptor (RXR) and the formed heterodimer binds to hormone response elements on the DNA. PXR, similar to other nuclear receptors contains a ligand-binding domain (LBD) and DNA-binding domain (DBD). |
==3D structures of pregnane X receptor== | ==3D structures of pregnane X receptor== | ||
Revision as of 07:24, 5 December 2013
| |||||||||||
