Cobra venom factor
From Proteopedia
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| - | <StructureSection load='3frp' scene='User:Gary_A._Toumas/Sandbox_1/Changing_colors/1' size='500' side='left' caption='Cobra Venom Factor α chain (red), β chain (blue), γ chain (yellow) complex with Ca+2 ion (PDB entry [[3frp]])'> | + | <StructureSection load='3frp' scene='User:Gary_A._Toumas/Sandbox_1/Changing_colors/1' size='500' side='left' caption='Cobra Venom Factor α chain (red), β chain (blue), γ chain (yellow) complex with Ca+2 ion (red) (PDB entry [[3frp]])'> |
===Structure=== | ===Structure=== | ||
Revision as of 09:27, 5 December 2013
Cobra Venom factor (CVF) is a stable functional co-factor of C3 and C5 convertases present in the venom of various rattle snake species. As part of the alternative pathway of immunological response to pathogens, C3 and C5 convertases are upregulated to induce the formation of membrane attack protein. CVF provides a functional and stable co-factor for convertase formation that can survive much longer than native co-factors and drastically increase the concentration of membrane attack protein which kills self cells and causes necrosis common to snake bites.
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3D Structures of Cobra venom factor
Updated on 05-December-2013
3pvm – CVF + hComplement C5
3frp – CVF α,β,γ chains
3hrz – CVF α,β,γ chains + hComplement C5 (mutant)
3hs0 – CVF α,β,γ chains + hComplement B (mutant)
3prx – CVF α,β,γ chains + hComplement C5 + superantigen-like protein 7
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Gary A. Toumas, Alexander Berchansky, Joel L. Sussman
