Sandbox Reserved 777
From Proteopedia
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== Introduction == | == Introduction == | ||
<Structure load='2H24' size='300' frame='true' align='right' caption='The interleukin 10 monomer. PDB 2H24' scene='Insert optional scene name here' /> | <Structure load='2H24' size='300' frame='true' align='right' caption='The interleukin 10 monomer. PDB 2H24' scene='Insert optional scene name here' /> | ||
| - | Interleukin 10 (IL-10) belongs to a class of proteins called cytokines. Cytokines are chemical messengers that are produced by and act on cells of the immune system. | + | Interleukin 10 (IL-10) belongs to a class of proteins called cytokines. Cytokines are chemical messengers that are produced by and act on cells of the immune system.<ref>National Institute of Allergy and Infectious Diseases, ”Immune Cells and their Products: Cytokines”. Web. 16Nov2013 <http://www.niaid.nih.gov/topics/immuneSystem/immuneCells/Pages/cytokines.aspx><ref/> It is also part of the IL-10 family of cytokines, which also includes IL-19, IL-20, IL-22, IL-24 and IL-26. This grouping was made based on similarities in structure, function, and location of the encoding genes.'''(2)''' IL-10 has also previously been called cytokine synthesis inhibitory factor (CSIF) because of its anti-inflammatory properties and ability to inhibit the production of other cytokines.'''(3)''' The ability to limit the immune response to pathogens is crucial to preventing self-inflicted damage to the host. This cytokine is expressed in many eukaryotic hosts, as well as some viruses. A quick protein BLAST of the human IL-10 sequence reveals homology with IL-10 of many other primate species, as well as that found in bats, horses, elephants, rodents, sheep, cats and birds. The remainder of this page will focus on human IL-10. |
== Structure == | == Structure == | ||
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== References == | == References == | ||
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1) National Institute of Allergy and Infectious Diseases, ”Immune Cells and their Products: Cytokines”. Web. 16Nov2013 <http://www.niaid.nih.gov/topics/immuneSystem/immuneCells/Pages/cytokines.aspx> | 1) National Institute of Allergy and Infectious Diseases, ”Immune Cells and their Products: Cytokines”. Web. 16Nov2013 <http://www.niaid.nih.gov/topics/immuneSystem/immuneCells/Pages/cytokines.aspx> | ||
Revision as of 14:51, 5 December 2013
| This Sandbox is Reserved from Sep 25, 2013, through Mar 31, 2014 for use in the course "BCH455/555 Proteins and Molecular Mechanisms" taught by Michael B. Goshe at the North Carolina State University. This reservation includes Sandbox Reserved 299, Sandbox Reserved 300 and Sandbox Reserved 760 through Sandbox Reserved 779. |
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Introduction
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Interleukin 10 (IL-10) belongs to a class of proteins called cytokines. Cytokines are chemical messengers that are produced by and act on cells of the immune system.[1]
