Chengfeng Ren/Sandbox1
From Proteopedia
(New page: =="RCF"==) |
|||
| Line 1: | Line 1: | ||
| - | == | + | ==IFN Categories and IFNβ-1a sources== |
| + | |||
| + | Interferons (IFNs) are a family of helical cytokines that mediate | ||
| + | antiviral, antiproliferative, and immune modulatory activities in | ||
| + | response to biological and chemical stimuli. Two types of IFN are recognized on | ||
| + | the basis of their physical and biological properties; type I, which | ||
| + | contains the monomeric IFNs-α,-β,-τ, and -ω, and type II, the | ||
| + | only member of which is the dimeric IFN-γ. Representatives of all | ||
| + | type I and type II IFNs are found in humans, except for IFN-τ, | ||
| + | which is found only in ruminant ungulates. There are 12 different human IFNs-α;each one | ||
| + | comprising a different subtype,although 14 different genes have | ||
| + | been identified, whereas human IFN-β, IFN-ω, and IFN-γare | ||
| + | encoded by single genes[1]. | ||
| + | |||
| + | Interferon-βhas two subtyes, interferon-β-1a and interferon-β-1b. Interferon-β-1a is naturally expressed in numerous cell types in human, including | ||
| + | fibroblasts, endothelial cells, epithelial cells and various leukocytes, however,Interferon-β-1b is produced in modified E. coli. | ||
| + | |||
| + | Here is a jpg clearly illustrating IFNs categories. | ||
| + | [[Image:IFN categories.jpg]] | ||
| + | |||
| + | ==Structure info. of IFNβ-1a== | ||
| + | ==IFNβ-1a biological activity and therapeutic effects== | ||
| + | ==Mechanism of action for IFNβ-1a== | ||
| + | ==Reference== | ||
| + | |||
| + | [1]''Protein Science'' (1999),''8'':1867–1877 | ||
| + | |||
| + | <Structure load='1a1u' size='500' frame='true' align='right' caption='IFN awesome' scene='IFN rocks' /> | ||
| + | <scene name='56/566503/Scene_one/1'>IFN turning around around</scene> | ||
| + | <scene name='56/566503/Fin_scene_1/1'>IFN showing polar/nonpolar section</scene> | ||
Revision as of 16:42, 6 December 2013
Contents |
IFN Categories and IFNβ-1a sources
Interferons (IFNs) are a family of helical cytokines that mediate antiviral, antiproliferative, and immune modulatory activities in response to biological and chemical stimuli. Two types of IFN are recognized on the basis of their physical and biological properties; type I, which contains the monomeric IFNs-α,-β,-τ, and -ω, and type II, the only member of which is the dimeric IFN-γ. Representatives of all type I and type II IFNs are found in humans, except for IFN-τ, which is found only in ruminant ungulates. There are 12 different human IFNs-α;each one comprising a different subtype,although 14 different genes have been identified, whereas human IFN-β, IFN-ω, and IFN-γare encoded by single genes[1].
Interferon-βhas two subtyes, interferon-β-1a and interferon-β-1b. Interferon-β-1a is naturally expressed in numerous cell types in human, including fibroblasts, endothelial cells, epithelial cells and various leukocytes, however,Interferon-β-1b is produced in modified E. coli.
Here is a jpg clearly illustrating IFNs categories.
Structure info. of IFNβ-1a
IFNβ-1a biological activity and therapeutic effects
Mechanism of action for IFNβ-1a
Reference
[1]Protein Science (1999),8:1867–1877
|
