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Ephrin receptor

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Revision as of 09:57, 10 December 2013

Image:3hei.png

Crystal Structure of ephrin receptor, 3hei

Template:STRUCTURE 3hei

Ephrin receptors (EPH) are components of the cell signaling pathways. They belong to the receptor tyrosine kinases. The extracellular ligand-binding domain (LBD) interacts with ephrin. EPH contains a sterile-α-motif (SAM) domain and a second fibronectin III domain (fn3). For more details see Ephrin Type-A Receptor.

1 3D Structures of ephrin receptors

3D Structures of ephrin receptors

Updated on 10-December-2013

Ephrin A1 receptor

3kka - hEPH A1 SAM+ hEPH A2 SAM – human
2k1l - hEPH A1 transmembrane domain – NMR
1x5a - hEPH A1 fn3 domain – NMR

Ephrin A2 receptor

3hpn, 3c8x - hEPH A2 LBD
2x10, 3fl7 - hEPH A2 ectodomain
2k9y, 3e8n - hEPH A2 transmembrane domain – NMR
1mqb - hEPH A2 kinase domain
3mx0, 1x11 - hEPH A2 ectodomain + ephrin A5
3hei, 3czu - hEPH A2 LBD + ephrin A1
3mbw - hEPH A2 LBD + carbohydrate-recognition domain + ephrin A1

Ephrin A3 receptor

2qo2, 2qob, 2gsf - hEPH A3 kinase domain
2qok, 2qol, 2qon, 2qoo, 2qod, 2qof, 2qoi - hEPH A3 kinase domain (mutant)
3fxx, 3fy2 – hEPH A3 kinase domain + peptide substrate
2qoq, 2qo7, 2qo9, 2qoc - hEPH A3 kinase domain + AMP-PNP
3dzq - hEPH A3 kinase domain + inhibitor

Ephrin A4 receptor

2wo1, 3ckh - hEPH A4 LBD
2wo3 - hEPH A4 LBD + ephrin A2 receptor-binding domain
2wo2, 3gxu - hEPH A4 LBD + ephrin B2 receptor-binding domain

Ephrin A5 receptor

2r2p - hEPH A5 kinase domain
1shx - mEPH A5 – mouse

Ephrin A7 receptor

3nru – hEPH A7 LBD
3h8m – hEPH A7 SAM
2rei - hEPH A7 kinase domain
3dko – hEPH A7 kinase domain + inhibitor

Ephrin A8 receptor

3kul - hEPH A8 kinase domain
1x5l – hEPH A8 fn3 domain – NMR
1ucv - hEPH A8 SAM – NMR

Ephrin B1 receptor

2eao – hEPH B1 SAM – NMR
2djs - hEPH B1 fn3 domain – NMR

Ephrin B2 receptor

3etp – hEPH B2
1f0m – mEPH B2 SAM
1sgg - mEPH B2 SAM – chicken - NMR
2vsk, 2vsm – hEPH B2 + Viral Hemagglutinin-neuraminidase
2qbx – hEPH B2 + peptide agonist
2hen - hEPH B2 kinase domain + ADP
1shw - mEPH B2 LBD + ephrin A5
1kgy - mEPH B2 LBD + ephrin B2 extracellular domain
1iko - mEPH B2 ectodomain

Ephrin B3 receptor

3p1i – hEPH B3 LBD

Ephrin B4 receptor

2qkq – hEPH B4 SAM
2e7h – hEPH B4 fn3 domain - NMR
2x9f - hEPH B4 kinase domain (mutant)
2vwx, 2vwz, 2vx0, 2vx1, 2vwu, 2vwv, 2vww – hEPH B4 + inhibitor
2hle, 2bba - hEPH B4 LBD + ephrin B2

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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 [[Image:3hei.png|left|200px|thumb|Crystal Structure of ephrin receptor, [[3hei]]]]
-{{STRUCTURE_3hei|  PDB=3hei  | SIZE=300| SCENE=Cadherin/Cv/1 |right|CAPTION=Human ephrin A2 receptor ligand-binding domain complex with ephrin A1, [[3hei]] }}
+{{STRUCTURE_3hei|  PDB=3hei  | SIZE=300| SCENE= |right|CAPTION=Human ephrin A2 receptor ligand-binding domain complex with ephrin A1, [[3hei]] }}
 '''Ephrin receptors''' (EPH) are components of the cell signaling pathways.  They belong to the receptor tyrosine kinases.  The extracellular ligand-binding domain (LBD) interacts with ephrin.  EPH contains a sterile-α-motif (SAM) domain and a second fibronectin III domain (fn3).  For  more details see [[ Ephrin Type-A Receptor]].