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Farnesyl diphosphate synthase

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{{STRUCTURE_3opm| PDB=3opm | SIZE=400| SCENE= |right|CAPTION=Human farnesyl diphosphate synthase tetramer complex with inhibitor [[3opm]] }}
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{{STRUCTURE_2opm| PDB=2opm | SIZE=400| SCENE= |right|CAPTION=Human farnesyl diphosphate synthase tetramer complex with lipophylic bisphosphonate inhibitor [[2opm]] }}
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'''FPS binary complexes'''
'''FPS binary complexes'''
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[[1yq7]], [[1yv5]], [[2f89]], [[2f8c]], [[2f92]], [[2f94]], [[2f9k]], [[2rah]], [[2opn]], [[2vf6]], [[3b7l]], [[3opm]], [[3n1v]], [[3n1w]], [[3n3l]], [[3n45]], [[3n46]], [[3n49]], [[3n5j]], [[3n6k]] – hFPS + inhibitor<br />
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[[1yq7]], [[1yv5]], [[2f89]], [[2f8c]], [[2f92]], [[2f94]], [[2f9k]], [[2rah]], [[2opn]], [[2vf6]], [[3b7l]], [[2opm]], [[3n1v]], [[3n1w]], [[3n3l]], [[3n45]], [[3n46]], [[3n49]], [[3n5j]], [[3n6k]] – hFPS + inhibitor<br />
[[2qis]], [[3cp6]], [[3rye]], [[3s4j]] - hFPS (mutant) + inhibitor<br />
[[2qis]], [[3cp6]], [[3rye]], [[3s4j]] - hFPS (mutant) + inhibitor<br />
[[2i19]], [[2ewg]], [[2ogd]], [[2p1c]], [[3dyg]], [[3dyh]], [[3efq]], [[3egt]] - TbFPS + inhibitor – ''Trypanosoma brucei''<br />
[[2i19]], [[2ewg]], [[2ogd]], [[2p1c]], [[3dyg]], [[3dyh]], [[3efq]], [[3egt]] - TbFPS + inhibitor – ''Trypanosoma brucei''<br />

Revision as of 10:52, 10 December 2013

Template:STRUCTURE 2opm

Farnesyl diphosphate synthase (FPS) also named farnesyl pyrophosphate synthase catalyzes the conversion of geranyl diphosphate (GDP) and isopentenyl diphosphate (IPP) to farnesyl diphosphate and diphosphate.

3D structures of farnesyl diphosphate synthase

Updated on 10-December-2013

1fps – cFPS – chicken
1ubv – cFPS (mutant)
1zw5, 2f7m – hFPS – human
1rtr– FPS – Staphylococcus aureus
1yhk – TcFPS – Trypanosoma cruzi
3lvs, 3m0g – FPS – Rhodobacter capsulatus

FPS binary complexes

1yq7, 1yv5, 2f89, 2f8c, 2f92, 2f94, 2f9k, 2rah, 2opn, 2vf6, 3b7l, 2opm, 3n1v, 3n1w, 3n3l, 3n45, 3n46, 3n49, 3n5j, 3n6k – hFPS + inhibitor
2qis, 3cp6, 3rye, 3s4j - hFPS (mutant) + inhibitor
2i19, 2ewg, 2ogd, 2p1c, 3dyg, 3dyh, 3efq, 3egt - TbFPS + inhibitor – Trypanosoma brucei
1ubw, 1ubx - cFPS (mutant) + GDP
1uby - cFPS (mutant) + dimethylallyl diphosphate
2for – FPS + IPP – Shigella flexneri
3id0 – TcFPS + inhibitor

FPS ternary complexes

2f8z - hFPS + IPP + inhibitor
1rqi – EcFPS + IPP + dimethylallyl S-thiolodiphosphate – Escherichia coli
1rqj - EcFPS + IPP + inhibitor
1yhl – TcFPS + dimethylallyl diphosphate + inhibitor
1yhm, 3iba, 3ick, 3icm, 3icn, 3icz - TcFPS + IPP + inhibitor
3ez3 - PvFPS + IPP + inhibitor – Plasmodium vivax
3dyf - TbFPS + IPP + inhibitor

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