4i8o

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==About this Structure==
==About this Structure==
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[[4i8o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I8O OCA].
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[[4i8o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I8O OCA].
==Reference==
==Reference==
<ref group="xtra">PMID:024112600</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:024112600</ref><references group="xtra"/><references/>
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[[Category: Escherichia coli k-12]]
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[[Category: Ecoli]]
[[Category: Dong, Y H.]]
[[Category: Dong, Y H.]]
[[Category: Gao, Z Q.]]
[[Category: Gao, Z Q.]]

Revision as of 12:11, 11 December 2013

Template:STRUCTURE 4i8o

Contents

Crystal structure of the toxin RnlA from Escherichia coli

Template:ABSTRACT PUBMED 24112600

Function

[RNLA_ECOLI] Toxic component of a toxin-antitoxin (TA) module. A stable (half-life 27.6 minutes) endoribonuclease that in the absence of cognate antitoxin RnlB causes generalized RNA degradation. Degrades late enterobacteria phage T4 mRNAs, protecting the host against T4 reproduction. Activity is inhibited by cognate antitoxin RnlB and by enterobacteria phage T4 protein Dmd. Targets cyaA mRNA.[1] [2] [3] [4]

About this Structure

4i8o is a 2 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA.

Reference

  • Wei Y, Gao ZQ, Otsuka Y, Naka K, Yonesaki T, Zhang H, Dong YH. Structure-function studies of Escherichia coli RnlA reveal a novel toxin structure involved in bacteriophage resistance. Mol Microbiol. 2013 Sep 30. doi: 10.1111/mmi.12409. PMID:24112600 doi:http://dx.doi.org/10.1111/mmi.12409
  1. ↑ Otsuka Y, Koga M, Iwamoto A, Yonesaki T. A role of RnlA in the RNase LS activity from Escherichia coli. Genes Genet Syst. 2007 Aug;82(4):291-9. PMID:17895580
  2. ↑ Iwamoto A, Lemire S, Yonesaki T. Post-transcriptional control of Crp-cAMP by RNase LS in Escherichia coli. Mol Microbiol. 2008 Dec;70(6):1570-8. doi: 10.1111/j.1365-2958.2008.06504.x. Epub, 2008 Oct 23. PMID:19019153 doi:http://dx.doi.org/10.1111/j.1365-2958.2008.06504.x
  3. ↑ Koga M, Otsuka Y, Lemire S, Yonesaki T. Escherichia coli rnlA and rnlB compose a novel toxin-antitoxin system. Genetics. 2011 Jan;187(1):123-30. doi: 10.1534/genetics.110.121798. Epub 2010 Oct, 26. PMID:20980243 doi:http://dx.doi.org/10.1534/genetics.110.121798
  4. ↑ Otsuka Y, Yonesaki T. Dmd of bacteriophage T4 functions as an antitoxin against Escherichia coli LsoA and RnlA toxins. Mol Microbiol. 2012 Feb;83(4):669-81. PMID:22403819

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