4c8d

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{{STRUCTURE_4c8d| PDB=4c8d | SCENE= }}
{{STRUCTURE_4c8d| PDB=4c8d | SCENE= }}
===Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)===
===Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)===
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==Function==
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[[http://www.uniprot.org/uniprot/KDM3B_HUMAN KDM3B_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.<ref>PMID:16603237</ref>
==About this Structure==
==About this Structure==
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[[4c8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8D OCA].
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[[4c8d]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4C8D OCA].
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[[Category: Homo sapiens]]
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Human]]
[[Category: Arrowsmith, C H.]]
[[Category: Arrowsmith, C H.]]
[[Category: Bountra, C.]]
[[Category: Bountra, C.]]

Revision as of 12:36, 11 December 2013

Template:STRUCTURE 4c8d

Contents

Crystal structure of JmjC domain of human histone 3 Lysine-specific demethylase 3B (KDM3B)

Function

[KDM3B_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.[1]

About this Structure

4c8d is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  1. ↑ Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell. 2006 May 5;125(3):483-95. Epub 2006 Apr 6. PMID:16603237 doi:http://dx.doi.org/S0092-8674(06)00385-0

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