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2rf3
From Proteopedia
(New page: 200px<br /><applet load="2rf3" size="350" color="white" frame="true" align="right" spinBox="true" caption="2rf3, resolution 1.75Å" /> '''Crystal Structure of...) |
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caption="2rf3, resolution 1.75Å" /> | caption="2rf3, resolution 1.75Å" /> | ||
'''Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles'''<br /> | '''Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles'''<br /> | ||
| + | |||
| + | ==Overview== | ||
| + | The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases. | ||
==About this Structure== | ==About this Structure== | ||
2RF3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=SPM:'>SPM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+B+308'>AC1</scene> and <scene name='pdbsite=AC2:Spm+Binding+Site+For+Residue+B+309'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF3 OCA]. | 2RF3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=SPM:'>SPM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+B+308'>AC1</scene> and <scene name='pdbsite=AC2:Spm+Binding+Site+For+Residue+B+309'>AC2</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF3 OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles., Pallan PS, Ittig D, Heroux A, Wawrzak Z, Leumann CJ, Egli M, Chem Commun (Camb). 2008 Feb 21;(7):883-5. Epub 2007 Dec 21. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18253536 18253536] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Egli, M.]] | [[Category: Egli, M.]] | ||
[[Category: Heroux, A.]] | [[Category: Heroux, A.]] | ||
[[Category: Ittig, D.]] | [[Category: Ittig, D.]] | ||
| - | [[Category: Leumann, C | + | [[Category: Leumann, C J.]] |
| - | [[Category: Pallan, P | + | [[Category: Pallan, P S.]] |
[[Category: Wawrzak, Z.]] | [[Category: Wawrzak, Z.]] | ||
[[Category: SPM]] | [[Category: SPM]] | ||
| Line 19: | Line 25: | ||
[[Category: x-ray crystal structure]] | [[Category: x-ray crystal structure]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:46:47 2008'' |
Revision as of 16:46, 21 February 2008
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Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles
Overview
The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.
About this Structure
2RF3 is a Single protein structure of sequence from [1] with and as ligands. Known structural/functional Sites: and . Full crystallographic information is available from OCA.
Reference
Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles., Pallan PS, Ittig D, Heroux A, Wawrzak Z, Leumann CJ, Egli M, Chem Commun (Camb). 2008 Feb 21;(7):883-5. Epub 2007 Dec 21. PMID:18253536
Page seeded by OCA on Thu Feb 21 18:46:47 2008
