4ixv

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'''Unreleased structure'''
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{{STRUCTURE_4ixv| PDB=4ixv | SCENE= }}
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===Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)===
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{{ABSTRACT_PUBMED_23886684}}
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The entry 4ixv is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN]] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
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Authors: Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Whitehouse, D., Beckett, P., Van Zandt, M.C., Ji, M.K., Ryder, T., Jagdmann, R., Andreoli, M., Olczak, J., Mazur, M., Czestkowski, W., Piotrowska, W., Schroeter, H., Golebiowski, A., Podjarny, A.
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==About this Structure==
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[[4ixv]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IXV OCA].
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Description: Crystal structure of human Arginase-2 complexed with inhbitor 2d
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==Reference==
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<ref group="xtra">PMID:023886684</ref><references group="xtra"/><references/>
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[[Category: Arginase]]
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[[Category: Andreoli, M.]]
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[[Category: Beckett, P.]]
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[[Category: Cousido-Siah, A.]]
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[[Category: Czestkowski, W.]]
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[[Category: Golebiowski, A.]]
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[[Category: Jagdmann, R.]]
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[[Category: Ji, M K.]]
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[[Category: Mazur, M.]]
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[[Category: Mitschler, A.]]
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[[Category: Olczak, J.]]
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[[Category: Piotrowska, W.]]
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[[Category: Podjarny, A.]]
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[[Category: Ruiz, F X.]]
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[[Category: Ryder, T.]]
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[[Category: Schroeter, H.]]
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[[Category: Whitehouse, D.]]
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[[Category: Zandt, M C.Van.]]
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[[Category: Alpha/beta fold]]
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[[Category: Arginine metabolism]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Metalloenzyme]]
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[[Category: Mitochondrion]]

Revision as of 13:37, 11 December 2013

Template:STRUCTURE 4ixv

Contents

Crystal structure of human Arginase-2 complexed with inhibitor 2d: {(5R)-5-amino-5-carboxy-5-[1-(4-chlorobenzyl)piperidin-4-yl]pentyl}(trihydroxy)borate(1-)

Template:ABSTRACT PUBMED 23886684

Function

[ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.

About this Structure

4ixv is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  • Golebiowski A, Whitehouse D, Beckett RP, Van Zandt M, Ji MK, Ryder TR, Jagdmann E, Andreoli M, Lee Y, Sheeler R, Conway B, Olczak J, Mazur M, Czestkowski W, Piotrowska W, Cousido-Siah A, Ruiz FX, Mitschler A, Podjarny A, Schroeter H. Synthesis of quaternary alpha-amino acid-based arginase inhibitors via the Ugi reaction. Bioorg Med Chem Lett. 2013 Sep 1;23(17):4837-41. doi: 10.1016/j.bmcl.2013.06.092., Epub 2013 Jul 8. PMID:23886684 doi:http://dx.doi.org/10.1016/j.bmcl.2013.06.092

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OCA

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