4iku

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-	'''Unreleased structure'''	+	{{STRUCTURE_4iku| PDB=4iku | SCENE= }}
		+	===Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with 2-((5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide===
		+	{{ABSTRACT_PUBMED_23767698}}
-	The entry 4iku is ON HOLD until Paper Publication	+	==Function==
		+	[[http://www.uniprot.org/uniprot/AMPM1_HUMAN AMPM1_HUMAN]] Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.<ref>PMID:16274222</ref> <ref>PMID:17114291</ref>
-	Authors: Addlagatta, A., Kishor, C., Arya, T.	+	==About this Structure==
		+	[[4iku]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IKU OCA].
-	Description: Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with 2-((5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide	+	==Reference==
		+	<ref group="xtra">PMID:023767698</ref><references group="xtra"/><references/>
		+	[[Category: Methionyl aminopeptidase]]
		+	[[Category: Addlagatta, A.]]
		+	[[Category: Arya, T.]]
		+	[[Category: Kishor, C.]]
		+	[[Category: Aminopeptidase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Pita-bread fold]]
		+	[[Category: Ribosome]]

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Revision as of 13:39, 11 December 2013

Template:STRUCTURE 4iku

Contents 1 Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with 2-((5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide 2 Function 3 About this Structure 4 Reference

Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with 2-((5-chloro-6-methyl-2-(pyridin-2-yl)pyrimidin-4-yl)amino)-3-phenylpropanamide

Template:ABSTRACT PUBMED 23767698

Function

[AMPM1_HUMAN] Removes the N-terminal methionine from nascent proteins. Required for normal progression through the cell cycle.^{[1] [2]}

About this Structure

4iku is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

• Kishor C, Arya T, Reddi R, Chen X, Saddanapu V, Marapaka AK, Gumpena R, Ma D, Liu JO, Addlagatta A. Identification, Biochemical and Structural Evaluation of Species-Specific Inhibitors against Type I Methionine Aminopeptidases. J Med Chem. 2013 Jun 27. PMID:23767698 doi:http://dx.doi.org/10.1021/jm400395p

1. ↑ Addlagatta A, Hu X, Liu JO, Matthews BW. Structural basis for the functional differences between type I and type II human methionine aminopeptidases. Biochemistry. 2005 Nov 15;44(45):14741-9. PMID:16274222 doi:10.1021/bi051691k
2. ↑ Hu X, Addlagatta A, Lu J, Matthews BW, Liu JO. Elucidation of the function of type 1 human methionine aminopeptidase during cell cycle progression. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18148-53. Epub 2006 Nov 17. PMID:17114291