4nkh

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'''Unreleased structure'''
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{{STRUCTURE_4nkh| PDB=4nkh | SCENE= }}
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===Crystal structure of SspH1 LRR domain===
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{{ABSTRACT_PUBMED_24248594}}
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The entry 4nkh is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/SSPH1_SALT1 SSPH1_SALT1]] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host PKN1. Down-modulates production of host proinflammatory cytokines by inhibiting NF-kappa-B-dependent gene expression, probably via interaction with PKN1.<ref>PMID:10564523</ref> <ref>PMID:12819095</ref> <ref>PMID:16611232</ref> <ref>PMID:18005683</ref>
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Authors: Keszei, A.F.A., Xiaojing, T., Mccormick, C., Zeqiraj, E., Rohde, J.R., Tyers, M., Sicheri, F.
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==About this Structure==
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[[4nkh]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NKH OCA].
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Description: Crystal structure of SspH1 LRR domain
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==Reference==
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<ref group="xtra">PMID:024248594</ref><references group="xtra"/><references/>
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[[Category: Keszei, A F.A.]]
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[[Category: Mccormick, C.]]
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[[Category: Rohde, J R.]]
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[[Category: Sicheri, F.]]
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[[Category: Tyers, M.]]
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[[Category: Xiaojing, T.]]
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[[Category: Zeqiraj, E.]]
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[[Category: E3 ligase substrate interaction domain]]
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[[Category: Leucine-rich repeat]]
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[[Category: Ligase]]

Revision as of 13:40, 11 December 2013

Template:STRUCTURE 4nkh

Contents

Crystal structure of SspH1 LRR domain

Template:ABSTRACT PUBMED 24248594

Function

[SSPH1_SALT1] Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Can ubiquitinate both ubiquitin and host PKN1. Down-modulates production of host proinflammatory cytokines by inhibiting NF-kappa-B-dependent gene expression, probably via interaction with PKN1.[1] [2] [3] [4]

About this Structure

4nkh is a 6 chain structure. Full crystallographic information is available from OCA.

Reference

  • Keszei AF, Tang X, McCormick C, Zeqiraj E, Rohde JR, Tyers M, Sicheri F. Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase. Mol Cell Biol. 2013 Nov 18. PMID:24248594 doi:http://dx.doi.org/10.1128/MCB.01360-13
  1. ↑ Miao EA, Scherer CA, Tsolis RM, Kingsley RA, Adams LG, Baumler AJ, Miller SI. Salmonella typhimurium leucine-rich repeat proteins are targeted to the SPI1 and SPI2 type III secretion systems. Mol Microbiol. 1999 Nov;34(4):850-64. PMID:10564523
  2. ↑ Haraga A, Miller SI. A Salmonella enterica serovar typhimurium translocated leucine-rich repeat effector protein inhibits NF-kappa B-dependent gene expression. Infect Immun. 2003 Jul;71(7):4052-8. PMID:12819095
  3. ↑ Haraga A, Miller SI. A Salmonella type III secretion effector interacts with the mammalian serine/threonine protein kinase PKN1. Cell Microbiol. 2006 May;8(5):837-46. PMID:16611232 doi:http://dx.doi.org/10.1111/j.1462-5822.2005.00670.x
  4. ↑ Rohde JR, Breitkreutz A, Chenal A, Sansonetti PJ, Parsot C. Type III secretion effectors of the IpaH family are E3 ubiquitin ligases. Cell Host Microbe. 2007 Mar 15;1(1):77-83. PMID:18005683 doi:10.1016/j.chom.2007.02.002

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OCA

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