2mb7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "2mb7" [edit=sysop:move=sysop])
Line 1: Line 1:
-
'''Unreleased structure'''
+
{{STRUCTURE_2mb7| PDB=2mb7 | SCENE= }}
 +
===Solution structure of MBD3 methylcytosine binding domain===
-
The entry 2mb7 is ON HOLD until Paper Publication
+
==Function==
 +
[[http://www.uniprot.org/uniprot/MBD3_HUMAN MBD3_HUMAN]] Acts as transcriptional repressor and plays a role in gene silencing. Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases.<ref>PMID:9774669</ref> <ref>PMID:10947852</ref> <ref>PMID:12124384</ref>
-
Authors: Williams Jr., D.C., Scarsdale, J.N.
+
==About this Structure==
 +
[[2mb7]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MB7 OCA].
-
Description: Solution structure of MBD3 methylcytosine binding domain
+
==Reference==
 +
<references group="xtra"/><references/>
 +
[[Category: Scarsdale, J N.]]
 +
[[Category: Williams, D C.]]
 +
[[Category: Chromatin]]
 +
[[Category: Dna methylation]]
 +
[[Category: Mbd3]]
 +
[[Category: Nurd]]
 +
[[Category: Transcription]]

Revision as of 13:42, 11 December 2013

Template:STRUCTURE 2mb7

Contents

Solution structure of MBD3 methylcytosine binding domain

Function

[MBD3_HUMAN] Acts as transcriptional repressor and plays a role in gene silencing. Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases.[1] [2] [3]

About this Structure

2mb7 is a 1 chain structure. Full experimental information is available from OCA.

Reference

  1. ↑ Hendrich B, Bird A. Identification and characterization of a family of mammalian methyl-CpG binding proteins. Mol Cell Biol. 1998 Nov;18(11):6538-47. PMID:9774669
  2. ↑ Tatematsu KI, Yamazaki T, Ishikawa F. MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase. Genes Cells. 2000 Aug;5(8):677-88. PMID:10947852
  3. ↑ Saito M, Ishikawa F. The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. J Biol Chem. 2002 Sep 20;277(38):35434-9. Epub 2002 Jul 17. PMID:12124384 doi:http://dx.doi.org/10.1074/jbc.M203455200

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2mb7"
Personal tools