4hi8
From Proteopedia
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| - | + | {{STRUCTURE_4hi8| PDB=4hi8 | SCENE= }} | |
| + | ===Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/ILK_HUMAN ILK_HUMAN]] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. [[http://www.uniprot.org/uniprot/LIMS1_HUMAN LIMS1_HUMAN]] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation. | ||
| - | + | ==About this Structure== | |
| - | + | [[4hi8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HI8 OCA]. | |
| - | + | [[Category: Non-specific serine/threonine protein kinase]] | |
| + | [[Category: Boggon, T J.]] | ||
| + | [[Category: Calderwood, D A.]] | ||
| + | [[Category: Chiswell, B P.]] | ||
| + | [[Category: Jakoncic, J.]] | ||
| + | [[Category: Stiegler, A L.]] | ||
| + | [[Category: Stojanoff, V.]] | ||
| + | [[Category: Ankyrin repeat lim domain]] | ||
| + | [[Category: Focal adhesion]] | ||
| + | [[Category: Ilk-pinch]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Signaling protein-signaling protein complex]] | ||
Revision as of 13:47, 11 December 2013
Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800
Function
[ILK_HUMAN] Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. [LIMS1_HUMAN] Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.
About this Structure
4hi8 is a 2 chain structure. Full crystallographic information is available from OCA.
