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4mso
From Proteopedia
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| - | + | {{STRUCTURE_4mso| PDB=4mso | SCENE= }} | |
| + | ===X-ray crystal structure of a serine hydroxymethyl transferase in apo form from Burkholderia cenocepacia=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/B4ECY9_BURCJ B4ECY9_BURCJ]] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).[HAMAP-Rule:MF_00051] | ||
| - | + | ==About this Structure== | |
| - | + | [[4mso]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4MSO OCA]. | |
| - | + | [[Category: Glycine hydroxymethyltransferase]] | |
| + | [[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]] | ||
| + | [[Category: National institute of allergy and infectious disease]] | ||
| + | [[Category: Niaid]] | ||
| + | [[Category: Pyridoxal phosphate]] | ||
| + | [[Category: Seattle structural genomics center for infectious disease]] | ||
| + | [[Category: Serine hydroxymethyl transferase]] | ||
| + | [[Category: Ssgcid]] | ||
| + | [[Category: Structural genomic]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 13:52, 11 December 2013
X-ray crystal structure of a serine hydroxymethyl transferase in apo form from Burkholderia cenocepacia
Function
[B4ECY9_BURCJ] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).[HAMAP-Rule:MF_00051]
About this Structure
4mso is a 2 chain structure. Full crystallographic information is available from OCA.
Categories: Glycine hydroxymethyltransferase | SSGCID, Seattle Structural Genomics Center for Infectious Disease. | National institute of allergy and infectious disease | Niaid | Pyridoxal phosphate | Seattle structural genomics center for infectious disease | Serine hydroxymethyl transferase | Ssgcid | Structural genomic | Transferase
