4nie
From Proteopedia
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| - | + | {{STRUCTURE_4nie| PDB=4nie | SCENE= }} | |
| + | ===Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | ||
| - | + | ==About this Structure== | |
| - | + | [[4nie]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4NIE OCA]. | |
| - | + | [[Category: Ma, Y L.]] | |
| + | [[Category: Yang, L Q.]] | ||
| + | [[Category: Ligand binding domain]] | ||
| + | [[Category: Nuclear receptor]] | ||
| + | [[Category: Transcription-agonist complex]] | ||
Revision as of 13:54, 11 December 2013
Crystal structure of the orphan nuclear receptor ROR(gamma)t ligand-binding domain in complex with small molecule ligand
Function
[RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
About this Structure
4nie is a 4 chain structure. Full crystallographic information is available from OCA.
