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Galectin
From Proteopedia
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<StructureSection load='1hlc' size='400' side='right' caption='Structure of human galectin-1 complex with lactose (PDB entry [[1hlc]])' scene=''> | <StructureSection load='1hlc' size='400' side='right' caption='Structure of human galectin-1 complex with lactose (PDB entry [[1hlc]])' scene=''> | ||
| - | '''Galectin''' (GAL) are lectins which bind | + | '''Galectin''' (GAL) are lectins which bind β-galactosidase (BGAL). GAL contains a carbohydrate recognition domain (CRD). GAL are known to inhibit chronic inflammation. The CRD is a beta-sandwich long enough to bind a tetrasaccharide.<br /> |
| + | * GAL-1 is thought to play a role as autocrine negative growth factor that regulates cell proliferation.<br /> | ||
| + | * GAL-2 is expressed primarily in gastrointestinal tract.<br /> | ||
| + | * GAL-3 has broad biological functionality.<br /> | ||
| + | * GAL-4 has 2 CRDs.<br /> | ||
| + | * GAL-7 is associated with epithelial cells.<br /> | ||
| + | * GAL-8 has a role in cellular defence against bacterial infection and vacuolar damage.<br /> | ||
| + | * GAL-9 affects eosinophil survival. <br /> | ||
| + | * GAL-10 or Charcot-Leyden crystal protein acts on biological membranes to regulate the multifunctional lysophospholipids. | ||
==3D structures of galectin== | ==3D structures of galectin== | ||
Revision as of 07:24, 15 December 2013
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