C-X-C motif chemokine
From Proteopedia
Michal Harel (Talk | contribs)
(New page: {{STRUCTURE_1qg7|right| PDB=1qg7 | SCENE= |CAPTION=CXCL12α dimer complex with sulfate, 1qg7 }} '''C-X-C motif chemokine''' (CXCL) are small chemokines.<br /> • CXCL10 or IP-10...)
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Revision as of 12:06, 16 December 2013
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| CXCL12α dimer complex with sulfate, 1qg7 | |||||||||
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
C-X-C motif chemokine (CXCL) are small chemokines.
• CXCL10 or IP-10 or interferon γ-induced protein 10 acts as chemoattractant for monocytes, T cells NK cells and dendritic cells. CXCL10 binds to the cell surface receptor CXCR3.
• CXCL11 or IP-9 or interferon γ-induced protein 9 acts as chemotactic for activated T cells.
• CXCL12 or Stromal-Derived-Factor-1 (SDF1) has a role in angiogenesis, tumor metastasis and the migration of cells from the liver to the bone marrow during embryogenesis.
• CXCL14 or BRAK acts as chemotactic for monocytes and inhibits angiogenesis.
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3D Structures of C-X-C motif chemokine
Updated on 16-December-2013
CXCL10
1lv9 – hCXCL – human – NMR
1o7z, 1o7y, 1o80 – hCXCL
2r3z – CXCL – mouse
CXCL11
1rjt – hCXCL
CXCL12
3D Structures of Stromal Derived Factor 1
Updated on 16-December-2013
2kec, 2ked, 2kee, 2sdf, 1sdf, 1vmc - hSDF1α – NMR - human
1qg7, 3hp3 - hSDF1α
2k0l, 2k01, 2kol – hSDF1α (mutant) – NMR
1a15, 3gv3 - hSDF1α (mutant)
2nwg - hSDF1α+heparin
2j7z - hSDF1α residues 22-89
2k03, 2k04, 2k05 - hSDF1α (mutant)+ hCXCR4 N-terminal (mutant)
CXCL14
2hdl – hCXCL – NMR
