Molecular Playground/Bacterial Chemotaxis Complex
From Proteopedia
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| - | <applet load='3UR1' size='400' color='white' frame='true' align='right' caption='A single ternary | + | <applet load='3UR1' size='400' color='white' frame='true' align='right' caption='A single asymmetric unit ternary complex with the truncated receptor, CheA, and CheW [[3UR1]]' scene='57/571407/Single_ternary_complex/1'/> |
One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst. | One of the [[CBI Molecules]] being studied in the [http://www.umass.edu/cbi/ University of Massachusetts Amherst Chemistry-Biology Interface Program] at UMass Amherst. | ||
| - | Bacterial chemotaxis is a method for cells to sense and adapt to chemicals in their environment. It is carried out by large arrays of membrane associated multi-protein complexes that form at the poles of the cells. The major players involved are the | + | Bacterial chemotaxis is a method for cells to sense and adapt to chemicals in their environment. It is carried out by large arrays of membrane associated multi-protein complexes that form at the poles of the cells. The major players involved are the transmembrane receptor, histidine kinase CheA, and scaffold/adaptor protein CheW. Repellants and attractants bind to the periplasmic domain of the receptor. The signal is then relayed within the cytoplasm to govern CheA's kinase activity, and ultimately lead to changes in swimming behavior. |
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===Structure=== | ===Structure=== | ||
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| + | The transmembrane receptor is a long, alpha helical homo-dimer with many domains. | ||
Revision as of 17:15, 16 December 2013
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One of the CBI Molecules being studied in the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst.
Bacterial chemotaxis is a method for cells to sense and adapt to chemicals in their environment. It is carried out by large arrays of membrane associated multi-protein complexes that form at the poles of the cells. The major players involved are the transmembrane receptor, histidine kinase CheA, and scaffold/adaptor protein CheW. Repellants and attractants bind to the periplasmic domain of the receptor. The signal is then relayed within the cytoplasm to govern CheA's kinase activity, and ultimately lead to changes in swimming behavior.
Structure
The transmembrane receptor is a long, alpha helical homo-dimer with many domains.
