Indole-3-glycerol phosphate synthase (IGPS) catalyzes the reversible transformation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (CDRP) to 1-C-(indol-e-yl)-glycerol 3-phosphate (IGP), CO2 and H2O. IGPS is part of the tryptophan biosynthesis.
3D structures of IGPS
1lgs, 3tc6, 3tc7 – SsIGPS + PO4 – Sulfolobus solfataricus
1juk, 2c3z, 3nyz – SsIGPS + SO4
4iww – SsIGPS (mutant) + SO4 + Co
4ix0 – SsIGPS (mutant) + SO4 + Ni
1jul – SsIGPS
1i4n – TmIGPS + SO4 – Thermotoga maritima
1j5t – TmIGPS
1vc4 – IGPS + SO4 – Thermus thermophilus
3qja – MtGPS + SO4 – Mycobacterium tuberculosis
4fb7 – MtIGPS
3tsm – IGPS + SO4 – Brucella melitensis
IGPS complex with reactants or derivatives
1a53 – SsIGPS + IGP
1lbf, 1lbl – SsIGPS + CDRP
3nz1 – SsIGPS (mutant) + SO4 + transition state analog
3t40 – MtIGPS + CPG
3t44 – MtIGPS + IGP + anthranilate
3t55 – MtIGPS + PMBA
3t78 – MtIGPS + fluoroanthranilate
