4li0
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | [[4li0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | [[4li0]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LI0 OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024072714</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024072714</ref><references group="xtra"/><references/> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Goody, R S.]] | [[Category: Goody, R S.]] | ||
[[Category: Guo, Z.]] | [[Category: Guo, Z.]] | ||
Revision as of 07:45, 18 December 2013
Contents |
Crystal structure of GDP-bound Rab8:GRAB
Template:ABSTRACT PUBMED 24072714
Function
[RAB8A_HUMAN] May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization.[1] [2] [R3GEF_HUMAN] Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B.
About this Structure
4li0 is a 6 chain structure with sequence from Human. Full crystallographic information is available from OCA.
Reference
- Guo Z, Hou X, Goody RS, Itzen A. Intermediates in the Guanine Nucleotide Exchange Reaction of Rab8 Catalyzed by Rabin8/GRAB. J Biol Chem. 2013 Sep 26. PMID:24072714 doi:http://dx.doi.org/10.1074/jbc.M113.498329
- ↑ Bryant DM, Datta A, Rodriguez-Fraticelli AE, Peranen J, Martin-Belmonte F, Mostov KE. A molecular network for de novo generation of the apical surface and lumen. Nat Cell Biol. 2010 Nov;12(11):1035-45. doi: 10.1038/ncb2106. Epub 2010 Oct 3. PMID:20890297 doi:10.1038/ncb2106
- ↑ Roland JT, Bryant DM, Datta A, Itzen A, Mostov KE, Goldenring JR. Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2789-94. doi:, 10.1073/pnas.1010754108. Epub 2011 Jan 31. PMID:21282656 doi:10.1073/pnas.1010754108
