4bub

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===CRYSTAL STRUCTURE OF MURE LIGASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH ADP===
===CRYSTAL STRUCTURE OF MURE LIGASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH ADP===
{{ABSTRACT_PUBMED_23826965}}
{{ABSTRACT_PUBMED_23826965}}
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==Function==
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[[http://www.uniprot.org/uniprot/MURE_THEMA MURE_THEMA]] Catalyzes the addition of both L- and D-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use meso-diaminopimelate as the amino acid substrate in vitro, although much less efficiently.<ref>PMID:16595662</ref>
==About this Structure==
==About this Structure==
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[[4bub]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BUB OCA].
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[[4bub]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43589 Atcc 43589]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BUB OCA].
==Reference==
==Reference==
<ref group="xtra">PMID:023826965</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:023826965</ref><references group="xtra"/><references/>
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[[Category: Thermotoga maritima]]
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[[Category: Atcc 43589]]
[[Category: Contreras-Martel, C.]]
[[Category: Contreras-Martel, C.]]
[[Category: Dessen, A.]]
[[Category: Dessen, A.]]

Revision as of 08:07, 18 December 2013

Template:STRUCTURE 4bub

Contents

CRYSTAL STRUCTURE OF MURE LIGASE FROM THERMOTOGA MARITIMA IN COMPLEX WITH ADP

Template:ABSTRACT PUBMED 23826965

Function

[MURE_THEMA] Catalyzes the addition of both L- and D-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Is also able to use meso-diaminopimelate as the amino acid substrate in vitro, although much less efficiently.[1]

About this Structure

4bub is a 2 chain structure with sequence from Atcc 43589. Full crystallographic information is available from OCA.

Reference

  • Favini-Stabile S, Contreras-Martel C, Thielens N, Dessen A. MreB and MurG as scaffolds for the cytoplasmic steps of peptidoglycan biosynthesis. Environ Microbiol. 2013 Jun 3. doi: 10.1111/1462-2920.12171. PMID:23826965 doi:10.1111/1462-2920.12171
  1. ↑ Boniface A, Bouhss A, Mengin-Lecreulx D, Blanot D. The MurE synthetase from Thermotoga maritima is endowed with an unusual D-lysine adding activity. J Biol Chem. 2006 Jun 9;281(23):15680-6. Epub 2006 Apr 4. PMID:16595662 doi:http://dx.doi.org/M506311200

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