4n0g
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | [[4n0g]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N0G OCA]. | + | [[4n0g]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N0G OCA]. |
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:024165892</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:024165892</ref><references group="xtra"/><references/> | ||
| + | [[Category: Arath]] | ||
[[Category: Phosphoprotein phosphatase]] | [[Category: Phosphoprotein phosphatase]] | ||
[[Category: Hang, J.]] | [[Category: Hang, J.]] | ||
Revision as of 08:35, 18 December 2013
Contents |
Crystal Structure of PYL13-PP2CA complex
Template:ABSTRACT PUBMED 24165892
Function
[P2C37_ARATH] Major negative regulator of abscisic acid (ABA) responses during seed germination and cold acclimation. Confers insensitivity to ABA. Modulates negatively the AKT2/3 activity, which mediates K(+) transport and membrane polarization during stress situations, probably by dephosphorylation. Prevent stomata closure by inactivating the S-type anion efflux channel SLAC1 and its activator SRK2E.[1] [2] [3] [4] [5] [6] [7] [PYL13_ARATH] Receptor for abscisic acid (ABA) required for ABA-mediated responses such as stomatal closure and germination inhibition. Inhibits the activity of group-A protein phosphatases type 2C (PP2Cs) when activated by ABA (By similarity).
About this Structure
4n0g is a 4 chain structure with sequence from Arath. Full crystallographic information is available from OCA.
Reference
- Li W, Wang L, Sheng X, Yan C, Zhou R, Hang J, Yin P, Yan N. Molecular basis for the selective and ABA-independent inhibition of PP2CA by PYL13. Cell Res. 2013 Oct 29. doi: 10.1038/cr.2013.143. PMID:24165892 doi:http://dx.doi.org/10.1038/cr.2013.143
- ↑ Sheen J. Mutational analysis of protein phosphatase 2C involved in abscisic acid signal transduction in higher plants. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):975-80. PMID:9448270
- ↑ Tahtiharju S, Palva T. Antisense inhibition of protein phosphatase 2C accelerates cold acclimation in Arabidopsis thaliana. Plant J. 2001 May;26(4):461-70. PMID:11439132
- ↑ Cherel I, Michard E, Platet N, Mouline K, Alcon C, Sentenac H, Thibaud JB. Physical and functional interaction of the Arabidopsis K(+) channel AKT2 and phosphatase AtPP2CA. Plant Cell. 2002 May;14(5):1133-46. PMID:12034902
- ↑ Yoshida T, Nishimura N, Kitahata N, Kuromori T, Ito T, Asami T, Shinozaki K, Hirayama T. ABA-hypersensitive germination3 encodes a protein phosphatase 2C (AtPP2CA) that strongly regulates abscisic acid signaling during germination among Arabidopsis protein phosphatase 2Cs. Plant Physiol. 2006 Jan;140(1):115-26. Epub 2005 Dec 9. PMID:16339800 doi:10.1104/pp.105.070128
- ↑ Kuhn JM, Boisson-Dernier A, Dizon MB, Maktabi MH, Schroeder JI. The protein phosphatase AtPP2CA negatively regulates abscisic acid signal transduction in Arabidopsis, and effects of abh1 on AtPP2CA mRNA. Plant Physiol. 2006 Jan;140(1):127-39. Epub 2005 Dec 16. PMID:16361522 doi:http://dx.doi.org/pp.105.070318
- ↑ Nishimura N, Yoshida T, Kitahata N, Asami T, Shinozaki K, Hirayama T. ABA-Hypersensitive Germination1 encodes a protein phosphatase 2C, an essential component of abscisic acid signaling in Arabidopsis seed. Plant J. 2007 Jun;50(6):935-49. Epub 2007 Apr 25. PMID:17461784 doi:http://dx.doi.org/10.1111/j.1365-313X.2007.03107.x
- ↑ Lee SC, Lan W, Buchanan BB, Luan S. A protein kinase-phosphatase pair interacts with an ion channel to regulate ABA signaling in plant guard cells. Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21419-24. doi:, 10.1073/pnas.0910601106. Epub 2009 Dec 2. PMID:19955427 doi:http://dx.doi.org/10.1073/pnas.0910601106
