From Proteopedia
(Difference between revisions)
proteopedia linkproteopedia link
|
|
| Line 1: |
Line 1: |
| - | {{STRUCTURE_4gse| PDB=4gse | SCENE= }}
| + | #REDIRECT [[4ifh]] This PDB entry is obsolete and replaced by 4ifh |
| - | ===Structure analysis of cysteine-free insulin degrading enzyme with BDM-44619, 4-methyl-N-({1-[(2S)-1-(naphthalen-2-yl)-4-nitroso-4-oxobutan-2-yl]-1H- 1,2,3-Triazol-4-yl}methyl)benzamide===
| + | |
| - | | + | |
| - | ==Function==
| + | |
| - | [[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | + | |
| - | | + | |
| - | ==About this Structure==
| + | |
| - | [[4gse]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSE OCA].
| + | |
| - | | + | |
| - | ==Reference==
| + | |
| - | <references group="xtra"/><references/>
| + | |
| - | [[Category: Homo sapiens]]
| + | |
| - | [[Category: Insulysin]]
| + | |
| - | [[Category: Deprez, B.]]
| + | |
| - | [[Category: Deprez-Poulain, R.]]
| + | |
| - | [[Category: Guo, Q.]]
| + | |
| - | [[Category: Tang, W J.]]
| + | |
| - | [[Category: Hydrolase]]
| + | |
| - | [[Category: Hydrolase-hydrolase inhibitor complex]]
| + | |
| - | [[Category: Insulin degrading enzyme]]
| + | |
Current revision
- REDIRECT 4ifh This PDB entry is obsolete and replaced by 4ifh
