4btx

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'''Unreleased structure'''
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{{STRUCTURE_4btx| PDB=4btx | SCENE= }}
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===Crystal structure of human vascular adhesion protein-1 in complex with pyridazinone inhibitors===
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{{ABSTRACT_PUBMED_24304424}}
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The entry 4btx is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/AOC3_HUMAN AOC3_HUMAN]] Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis.<ref>PMID:9653080</ref> <ref>PMID:17400359</ref> <ref>PMID:19588076</ref>
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Authors: Bligt-Linden, E., Pihlavisto, M., Szatmari, I., Otwinowski, Z., Smith, D.J., Lazar, L., Fulop, F., Salminen, T.A.
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==About this Structure==
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[[4btx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTX OCA].
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Description: Crystal structure of human vascular adhesion protein-1 in complex with pyridazinone inhibitors
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==Reference==
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<ref group="xtra">PMID:024304424</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Primary-amine oxidase]]
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[[Category: Bligt-Linden, E.]]
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[[Category: Fulop, F.]]
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[[Category: Lazar, L.]]
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[[Category: Otwinowski, Z.]]
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[[Category: Pihlavisto, M.]]
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[[Category: Salminen, T A.]]
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[[Category: Smith, D J.]]
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[[Category: Szatmari, I.]]
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[[Category: Oxidoreductase]]

Revision as of 10:21, 18 December 2013

Template:STRUCTURE 4btx

Contents

Crystal structure of human vascular adhesion protein-1 in complex with pyridazinone inhibitors

Template:ABSTRACT PUBMED 24304424

Function

[AOC3_HUMAN] Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis.[1] [2] [3]

About this Structure

4btx is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Bligt-Linden E, Pihlavisto M, Szatmari I, Otwinowski Z, Smith DJ, Lazar L, Fulop F, Salminen TA. Novel Pyridazinone Inhibitors for Vascular Adhesion Protein-1 (VAP-1): Old Target-New Inhibition Mode. J Med Chem. 2013 Dec 13. PMID:24304424 doi:http://dx.doi.org/10.1021/jm401372d
  1. ↑ Smith DJ, Salmi M, Bono P, Hellman J, Leu T, Jalkanen S. Cloning of vascular adhesion protein 1 reveals a novel multifunctional adhesion molecule. J Exp Med. 1998 Jul 6;188(1):17-27. PMID:9653080
  2. ↑ Bour S, Daviaud D, Gres S, Lefort C, Prevot D, Zorzano A, Wabitsch M, Saulnier-Blache JS, Valet P, Carpene C. Adipogenesis-related increase of semicarbazide-sensitive amine oxidase and monoamine oxidase in human adipocytes. Biochimie. 2007 Aug;89(8):916-25. Epub 2007 Feb 24. PMID:17400359 doi:http://dx.doi.org/10.1016/j.biochi.2007.02.013
  3. ↑ Kaitaniemi S, Elovaara H, Gron K, Kidron H, Liukkonen J, Salminen T, Salmi M, Jalkanen S, Elima K. The unique substrate specificity of human AOC2, a semicarbazide-sensitive amine oxidase. Cell Mol Life Sci. 2009 Aug;66(16):2743-57. doi: 10.1007/s00018-009-0076-5. Epub , 2009 Jul 9. PMID:19588076 doi:http://dx.doi.org/10.1007/s00018-009-0076-5

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