4n5d

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m (Protected "4n5d" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4n5d| PDB=4n5d | SCENE= }}
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===Tailoring Small Molecules for an Allosteric Site on Procaspase-6: Cpd1===
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{{ABSTRACT_PUBMED_24259468}}
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The entry 4n5d is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN]] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
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Authors: Murray, J.M., Steffek, M.
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==About this Structure==
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[[4n5d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4N5D OCA].
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Description: Tailoring Small Molecules for an Allosteric Site on Procaspase-6: Cpd1
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==Reference==
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<ref group="xtra">PMID:024259468</ref><references group="xtra"/><references/>
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[[Category: Caspase-6]]
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[[Category: Murray, J M.]]
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[[Category: Steffek, M.]]
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[[Category: Allosteric]]
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[[Category: Caspase-6 zymogen]]
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[[Category: Cysteine protease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Procaspse-6]]
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[[Category: Structure based drug design]]

Revision as of 10:23, 18 December 2013

Template:STRUCTURE 4n5d

Contents

Tailoring Small Molecules for an Allosteric Site on Procaspase-6: Cpd1

Template:ABSTRACT PUBMED 24259468

Function

[CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.

About this Structure

4n5d is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, Arkin MR, Flygare J, Renslo AR. Tailoring Small Molecules for an Allosteric Site on Procaspase-6. ChemMedChem. 2013 Nov 20. doi: 10.1002/cmdc.201300424. PMID:24259468 doi:http://dx.doi.org/10.1002/cmdc.201300424

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OCA

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