4kr1

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'''Unreleased structure'''
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{{STRUCTURE_4kr1| PDB=4kr1 | SCENE= }}
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===Crystal structure of the kinetechore protein Iml3 from budding yeast===
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{{ABSTRACT_PUBMED_24311582}}
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The entry 4kr1 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/IML3_YEAST IML3_YEAST]] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.<ref>PMID:11361335</ref> <ref>PMID:15241623</ref>
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Authors: Tao, Y., Guo, Q., Teng, M.
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==About this Structure==
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[[4kr1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KR1 OCA].
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Description: Crystal structure of a yeast kinetechore protein
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==Reference==
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<ref group="xtra">PMID:024311582</ref><references group="xtra"/><references/>
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[[Category: Guo, Q.]]
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[[Category: Tao, Y.]]
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[[Category: Teng, M.]]
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[[Category: Cell cycle]]
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[[Category: Chromosome segregation]]
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[[Category: Kinetochore protein]]

Revision as of 10:24, 18 December 2013

Template:STRUCTURE 4kr1

Contents

Crystal structure of the kinetechore protein Iml3 from budding yeast

Template:ABSTRACT PUBMED 24311582

Function

[IML3_YEAST] Component of the central kinetochore, which mediates the attachment of the centromere to the mitotic spindle by forming essential interactions between the microtubule-associated outer kinetochore proteins and the centromere-associated inner kinetochore proteins. Required for establishing bipolar spindle-microtubule attachments and proper chromosome segregation.[1] [2]

About this Structure

4kr1 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Guo Q, Tao Y, Liu H, Teng M, Li X. Structural insights into the role of the Chl4-Iml3 complex in kinetochore assembly. Acta Crystallogr D Biol Crystallogr. 2013 Dec;69(Pt 12):2412-9. doi:, 10.1107/S0907444913022397. Epub 2013 Nov 19. PMID:24311582 doi:http://dx.doi.org/10.1107/S0907444913022397
  1. ↑ Ghosh SK, Poddar A, Hajra S, Sanyal K, Sinha P. The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation. Mol Genet Genomics. 2001 Apr;265(2):249-57. PMID:11361335
  2. ↑ Ghosh SK, Sau S, Lahiri S, Lohia A, Sinha P. The Iml3 protein of the budding yeast is required for the prevention of precocious sister chromatid separation in meiosis I and for sister chromatid disjunction in meiosis II. Curr Genet. 2004 Aug;46(2):82-91. Epub 2004 Jul 6. PMID:15241623 doi:http://dx.doi.org/10.1007/s00294-004-0516-6

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