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3wi1

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_3wi1| PDB=3wi1 | SCENE= }}
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===P453H/I471T mutant of PB2 middle domain from influenza virus A/Puerto Rico/8/34(H1N1) with m7GTP===
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{{ABSTRACT_PUBMED_24312396}}
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The entry 3wi1 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PB2_I34A1 PB2_I34A1]] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).
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Authors: Tsurumura, T., Yoshida, T., Tsuge, H.
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==About this Structure==
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[[3wi1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WI1 OCA].
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Description: P453H/I471T mutant of PB2 middle domain from influenza virus A/Puerto Rico/8/34(H1N1) with m7GTP
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==Reference==
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<ref group="xtra">PMID:024312396</ref><references group="xtra"/><references/>
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[[Category: Tsuge, H.]]
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[[Category: Tsurumura, T.]]
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[[Category: Yoshida, T.]]
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[[Category: Cap binding]]
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[[Category: Influenza a virus]]
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[[Category: Middle domain]]
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[[Category: Pb2]]
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[[Category: Viral protein]]

Revision as of 10:25, 18 December 2013

Template:STRUCTURE 3wi1

Contents

P453H/I471T mutant of PB2 middle domain from influenza virus A/Puerto Rico/8/34(H1N1) with m7GTP

Template:ABSTRACT PUBMED 24312396

Function

[PB2_I34A1] Involved in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. Binds the cap of the target pre-RNA which is subsequently cleaved by PB1. May play a role in genome replication (By similarity).

About this Structure

3wi1 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Tsurumura T, Qiu H, Yoshida T, Tsumori Y, Hatakeyama D, Kuzuhara T, Tsuge H. Conformational Polymorphism of m(7)GTP in Crystal Structure of the PB2 Middle Domain from Human Influenza A Virus. PLoS One. 2013 Nov 29;8(11):e82020. doi: 10.1371/journal.pone.0082020. PMID:24312396 doi:http://dx.doi.org/10.1371/journal.pone.0082020

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OCA

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