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4cbo

From Proteopedia

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m (Protected "4cbo" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{Large structure}}
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{{STRUCTURE_4cbo| PDB=4cbo | SCENE= }}
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===Crystal structure of Complement Factor D mutant R202A after ensemble refinement===
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The entry 4cbo is ON HOLD
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==Disease==
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[[http://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN]] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:[http://omim.org/entry/613912 613912]]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.
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Authors: Forneris, F., Burnley, B.T., Gros, P.
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==Function==
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[[http://www.uniprot.org/uniprot/CFAD_HUMAN CFAD_HUMAN]] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.
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Description: Crystal structure of Complement Factor D mutant R202A after ensemble refinement
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==About this Structure==
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[[4cbo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CBO OCA].
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[[Category: Complement factor D]]
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[[Category: Burnley, B T.]]
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[[Category: Forneris, F.]]
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[[Category: Gros, P.]]
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[[Category: Ensemble refinement]]
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[[Category: Factor d]]
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[[Category: Hydrolase]]

Revision as of 10:34, 18 December 2013

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Template:STRUCTURE 4cbo

Contents

Crystal structure of Complement Factor D mutant R202A after ensemble refinement

Disease

[CFAD_HUMAN] Defects in CFD are the cause of complement factor D deficiency (CFDD) [MIM:613912]. CFDD is an immunologic disorder characterized by increased susceptibility to bacterial infections, particularly Neisseria infections, due to a defect in the alternative complement pathway.

Function

[CFAD_HUMAN] Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

About this Structure

4cbo is a 2 chain structure. Full crystallographic information is available from OCA.

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OCA

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