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4ft8

From Proteopedia

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m (Protected "4ft8" [edit=sysop:move=sysop])
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'''Unreleased structure'''
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{{STRUCTURE_4ft8| PDB=4ft8 | SCENE= }}
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===E. coli Catabolite Activator Protein with Cobalt and Sulfate Ligands===
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The entry 4ft8 is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI]] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
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Authors: Rao, R., Lawson, C.L.
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==About this Structure==
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[[4ft8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FT8 OCA].
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Description: E. coli Catabolite Activator Protein with Cobalt and Sulfate Ligands
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Lawson, C L.]]
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[[Category: Rao, R.]]
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[[Category: Cobalt binding]]
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[[Category: Dna binding protein]]
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[[Category: Sulfate binding]]
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[[Category: Transcription activator]]
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[[Category: Winged helix-turn-helix]]

Revision as of 10:35, 18 December 2013

Template:STRUCTURE 4ft8

Contents

E. coli Catabolite Activator Protein with Cobalt and Sulfate Ligands

Function

[CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.[1]

About this Structure

4ft8 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Aiba H. Transcription of the Escherichia coli adenylate cyclase gene is negatively regulated by cAMP-cAMP receptor protein. J Biol Chem. 1985 Mar 10;260(5):3063-70. PMID:2982847

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