4jgv

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'''Unreleased structure'''
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{{STRUCTURE_4jgv| PDB=4jgv | SCENE= }}
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===Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN===
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The entry 4jgv is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/NR4A1_HUMAN NR4A1_HUMAN]] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.<ref>PMID:15466594</ref>
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Authors: Zhang, Q., Li, F., Li, A., Tian, X., Wan, W., Wan, Y., Chen, H., Xing, Y., Wu, Q., Lin, T.
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==About this Structure==
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[[4jgv]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGV OCA].
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Description: Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Chen, H.]]
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[[Category: Li, A.]]
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[[Category: Li, F.]]
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[[Category: Lin, T.]]
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[[Category: Tian, X.]]
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[[Category: Wan, W.]]
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[[Category: Wan, Y.]]
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[[Category: Wu, Q.]]
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[[Category: Xing, Y.]]
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[[Category: Zhang, Q.]]
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[[Category: Transcription]]

Revision as of 10:38, 18 December 2013

Template:STRUCTURE 4jgv

Contents

Crystal Structure of Human Nur77 Ligand-binding Domain in Complex with THPN

Function

[NR4A1_HUMAN] Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3' (By similarity). May inhibit NF-kappa-B transactivation of IL2.[1]

About this Structure

4jgv is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Harant H, Lindley IJ. Negative cross-talk between the human orphan nuclear receptor Nur77/NAK-1/TR3 and nuclear factor-kappaB. Nucleic Acids Res. 2004 Oct 5;32(17):5280-90. Print 2004. PMID:15466594 doi:10.1093/nar/gkh856

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OCA

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