Janus kinase
From Proteopedia
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[[Image:3tjc.png|left|200px|thumb|Crystal structure of JAK2 complex with inhibitor [[3tjc]]]] | [[Image:3tjc.png|left|200px|thumb|Crystal structure of JAK2 complex with inhibitor [[3tjc]]]] | ||
| - | {{STRUCTURE_3tjc| PDB=3tjc | SIZE=350| SCENE= |right|CAPTION=JAK2 complex with inhibitor [[3tjc]] }} | + | {{STRUCTURE_3tjc| PDB=3tjc | SIZE=350| SCENE= |right|CAPTION=JAK2 complex with inhibitor thienopyridine [[3tjc]] }} |
Revision as of 09:03, 19 December 2013
Janus kinase (JAK) are nonreceptor tyrosine kinases which transduces cytokine-mediated signals via the JAK-STAT pathway. The JAK-STAT pathway transmits signals through the cell membrane to DNA promoters thus causing transcription. The name JAK is derived from Just Another Kinase. JAK proteins contain 2 phosphate-transfer domains, one with kinase activity using a phosphotyrosine (PTyr) and the other a pseudokinase domain which negatively regulates the kinase domain. The JAK family members are JAK1, JAK2, JAK3 and TYK2. JAK1 and TYK2 are involved in signaling by members of type I and type II cytokine receptors .JAK2 is involved in signaling by members of the interferon receptors (type II cytokines). JAK3 is predominantly active in immune cells. JAK3 is activated by cytokines whose receptors contain the common γ chain subunit (interleukin 2,4,7,9,15,21). TYK2 is a component of type I and type III interferon signaling pathways.
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3D Structures of Janus kinase 2
Updated on 19-December-2013
JAK1 kinase domain
4e4l, 4e4n, 4e5w, 4ehz, 4ei4, 4fk6 – hJAK1 kinase domain + PTyr + inhibitor - human
JAK2 kinase domain
2b7a, 3fup, 4e6d, 4e6q, 4f08 – hJAK2 kinase domain (mutant) + PTyr + inhibitor
3ugc, 4bbe, 4bbf, 3zmm – hJAK2 kinase domain (mutant) + inhibitor
3e62, 3e63, 3e64, 2w1i, 3io7, 3iok, 3kck, 3jy9, 3lpb, 3krr, 3q32, 3tjc, 3tjd, 3rvg, 4aqc, 4e4m, 4f09, 4hge – hJAK2 kinase domain + PTyr + inhibitor
4gl9 – mJAK2 kinase domain + PTyr + inhibitor + suppressor of cytokine signaling 3 + interleukin 6 receptor subunit β - mouse
JAK2 pseudokinase domain
3ugc – hJAK2 pseudokinase domain (mutant)
4fvq, 4fvr – hJAK2 pseudokinase domain (mutant) + ATP
JAK3 kinase domain
1yvj – hJAK3 kinase domain (mutant) + PTyr + staurosporine analog
3lxk, 3lxl – hJAK3 kinase domain (mutant) + PTyr + inhibitor
3pjc – hJAK3 kinase domain + inhibitor
4hvd, 4hvg, 4hvh, 4hvi, 3zc6 – hJAK3 kinase domain (mutant) + inhibitor
TYK2 kinase domain
3lxn, 3lxp – hTYK2 kinase domain (mutant) + PTyr + inhibitor
3nyx, 3nz0 – hTYK2 kinase domain (mutant) + inhibitor
4e1z, 4e20 – mTYK2 kinase domain (mutant) + inhibitor
TYK2 pseudokinase domain
3zon – hTYK2 pseudokinase domain + inhibitor
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
