Mitogen-activated protein kinase kinase

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[[Image:3e8n.png|left|thumb|300px|Crystal Structure of the Mitogen-activated protein kinase kinase, [[3e8n]]]]
[[Image:3e8n.png|left|thumb|300px|Crystal Structure of the Mitogen-activated protein kinase kinase, [[3e8n]]]]
{{STRUCTURE_1sko| right| PDB=1sko | SCENE= |CAPTION=Mitogen-activated protein kinase kinase (grey) complex with late endosomal/lysosomal MP1 interacting protein (green), [[1sko]] }}
{{STRUCTURE_1sko| right| PDB=1sko | SCENE= |CAPTION=Mitogen-activated protein kinase kinase (grey) complex with late endosomal/lysosomal MP1 interacting protein (green), [[1sko]] }}
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Revision as of 11:00, 22 December 2013

Image:3e8n.png
Crystal Structure of the Mitogen-activated protein kinase kinase, 3e8n

Template:STRUCTURE 1sko
















Mitogen-activated protein kinase kinase (MAP2K) are serine/threonine kinases which regulate various cellular activities in response to extracellular stimuli by mitogens, heat shock and more. MAP2K is part of the MAPK cascade which consists also of MAPK and MAP3K which are activated by phosphorylation. MAP2K activates MAPK. The images on the left and right correspond to one representative MAP2K structure, i.e. the human MAP2K1 (3e8n).

Contents






3D Structures of Mitogen-activated protein kinase kinase

Update November 2011

MAP2K1

3mbl, 3e8n, 3dy7, 3eqb, 2p55 – hMAP2K1 kinase domain +MgADP+ligand - human
3eqc – hMAP2K1 kinase domain+ATP-Gs+Mg2P
3eqd - hMAP2K1 kinase domain (mutant)+ATP-Gs+Mg2P
3eqf - hMAP2K1 kinase domain (mutant)+inhibitor+Mg2P
3eqg, 3eqi - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd
3eqh - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+inhibitor
3orn - hMAP2K1 kinase domain +MgAMP-PNP +inhibitor
3os3, 3pp1 - hMAP2K1 kinase domain + MgATP +inhibitor
3eqi - hMAP2K1 kinase domain (mutant)+ADP+Mg2P+Pd
3dv3 - hMAP2K1 residues 62-382+inhibitor
1s9j – hMAP2K1 +MgATP+ligand
1sko - hMAP2K1+P14
3cpt - hMAP2K1+P14 (mutant)
2y4i – MAP2K1 + kinase suppressor of RAS 2 - rabbit
1vet, 1veu - MAP2K1+P14 - mouse


MAP2K2

1s9i – hMAP2K2 +MgATP+ligand
1jky - hMAP2K2 + Anthrax lethal factor

MAP2K3

2o2v – hMAP2K3+ hMAP3K5

MAP2K4

3aln - hMAP2K4 kinase domain +AMPPNP
3alo - hMAP2K4 kinase domain + P38 peptide

MAP2K5

1p38 – hMAP2K5+hMAP2KK2

MAP2K6

3an0 - hMAP2K6
3enm – hMAP2K6 (mutant)
3fme – hMAP2K6 kinase domain (mutant)

MAP2K7

2dyl – hMAP2K7 kinase domain (mutant)

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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