4btj

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==About this Structure==
==About this Structure==
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[[4btj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTJ OCA].
+
[[4btj]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BTJ OCA].
==Reference==
==Reference==
<ref group="xtra">PMID:024039150</ref><references group="xtra"/><references/>
<ref group="xtra">PMID:024039150</ref><references group="xtra"/><references/>
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[[Category: Homo sapiens]]
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[[Category: Human]]
[[Category: Dekker, N.]]
[[Category: Dekker, N.]]
[[Category: Hillertz, P.]]
[[Category: Hillertz, P.]]

Revision as of 08:36, 25 December 2013

Template:STRUCTURE 4btj

Contents

TTBK1 in complex with ATP

Template:ABSTRACT PUBMED 24039150

Function

[TTBK1_HUMAN] Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU.[1]

About this Structure

4btj is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA.

Reference

  • Xue Y, Wan PT, Hillertz P, Schweikart F, Zhao Y, Wissler L, Dekker N. X-ray Structural Analysis of Tau-Tubulin Kinase 1 and Its Interactions with Small Molecular Inhibitors. ChemMedChem. 2013 Sep 13. doi: 10.1002/cmdc.201300274. PMID:24039150 doi:10.1002/cmdc.201300274
  1. Sato S, Cerny RL, Buescher JL, Ikezu T. Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation. J Neurochem. 2006 Sep;98(5):1573-84. PMID:16923168 doi:JNC4059

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