4a57

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:4a57.png|left|200px]]
 
- 
-
<!--
 
-
The line below this paragraph, containing "STRUCTURE_4a57", creates the "Structure Box" on the page.
 
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
 
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
 
-
or leave the SCENE parameter empty for the default display.
 
-
-->
 
{{STRUCTURE_4a57| PDB=4a57 | SCENE= }}
{{STRUCTURE_4a57| PDB=4a57 | SCENE= }}
- 
===CRYSTAL STRUCTURE OF TOXOPLASMA GONDII NUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 3 (NTPDASE3)===
===CRYSTAL STRUCTURE OF TOXOPLASMA GONDII NUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 3 (NTPDASE3)===
 +
{{ABSTRACT_PUBMED_22130673}}
-
 
+
==Function==
-
<!--
+
[[http://www.uniprot.org/uniprot/NTP1_TOXGO NTP1_TOXGO]] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite and may contribute to intracellular survival and virulence. NTPAse-I has a specific activity 4.5-fold higher than NTPAse-II in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).
-
The line below this paragraph, {{ABSTRACT_PUBMED_22130673}}, adds the Publication Abstract to the page
+
-
(as it appears on PubMed at http://www.pubmed.gov), where 22130673 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_22130673}}
+
==About this Structure==
==About this Structure==
-
[[4a57]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxoplasma_gondii Toxoplasma gondii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A57 OCA].
+
[[4a57]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Toxgo Toxgo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A57 OCA].
==Reference==
==Reference==
-
<ref group="xtra">PMID:022130673</ref><references group="xtra"/>
+
<ref group="xtra">PMID:022130673</ref><references group="xtra"/><references/>
[[Category: Nucleoside-triphosphatase]]
[[Category: Nucleoside-triphosphatase]]
-
[[Category: Toxoplasma gondii]]
+
[[Category: Toxgo]]
[[Category: Krug, U.]]
[[Category: Krug, U.]]
[[Category: Straeter, N.]]
[[Category: Straeter, N.]]
[[Category: Zebisch, M.]]
[[Category: Zebisch, M.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
 +
[[Category: Ntpdase]]

Revision as of 08:44, 25 December 2013

Template:STRUCTURE 4a57

Contents

CRYSTAL STRUCTURE OF TOXOPLASMA GONDII NUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 3 (NTPDASE3)

Template:ABSTRACT PUBMED 22130673

Function

[NTP1_TOXGO] May perform an important processing step in the conversion of high energy nucleotides prior to uptake by the parasite and may contribute to intracellular survival and virulence. NTPAse-I has a specific activity 4.5-fold higher than NTPAse-II in hydrolysis of ATP. The primary difference between these isozymes lies in their ability to hydrolyze nucleoside triphosphate versus diphosphate substrates. While NTPAse-II hydrolyzes ATP to ADP and ADP to AMP at almost the same rate, NTPAse-I hydrolyzes ADP to AMP at a much slower rate (0.7% of the rate for ATP).

About this Structure

4a57 is a 4 chain structure with sequence from Toxgo. Full crystallographic information is available from OCA.

Reference

  • Krug U, Zebisch M, Krauss M, Strater N. Structural insight into the activation mechanism of Toxoplasma gondii nucleoside triphosphate diphosphohydrolases by disulfide reduction. J Biol Chem. 2011 Nov 30. PMID:22130673 doi:10.1074/jbc.M111.294348

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4a57"
Personal tools