3sgl

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[[Image:3sgl.png|left|200px]]
 
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{{STRUCTURE_3sgl| PDB=3sgl | SCENE= }}
{{STRUCTURE_3sgl| PDB=3sgl | SCENE= }}
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===The crystal structure of MnmC from Yersinia pestis bound with FAD and SAM===
===The crystal structure of MnmC from Yersinia pestis bound with FAD and SAM===
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{{ABSTRACT_PUBMED_23617613}}
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==Function==
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[[http://www.uniprot.org/uniprot/MNMC_YERPE MNMC_YERPE]] Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity).
==About this Structure==
==About this Structure==
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[[3sgl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Yersinia_pestis Yersinia pestis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGL OCA].
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[[3sgl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGL OCA].
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[[Category: Yersinia pestis]]
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==Reference==
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<ref group="xtra">PMID:023617613</ref><references group="xtra"/><references/>
[[Category: Almo, S C.]]
[[Category: Almo, S C.]]
[[Category: Kim, J.]]
[[Category: Kim, J.]]

Revision as of 08:55, 25 December 2013

Template:STRUCTURE 3sgl

Contents

The crystal structure of MnmC from Yersinia pestis bound with FAD and SAM

Template:ABSTRACT PUBMED 23617613

Function

[MNMC_YERPE] Catalyzes the last two steps in the biosynthesis of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity).

About this Structure

3sgl is a 1 chain structure with sequence from "bacillus_pestis"_(lehmann_and_neumann_1896)_migula_1900 "bacillus pestis" (lehmann and neumann 1896) migula 1900. Full crystallographic information is available from OCA.

Reference

  • Kim J, Almo SC. Structural basis for hypermodification of the wobble uridine in tRNA by bifunctional enzyme MnmC. BMC Struct Biol. 2013 Apr 24;13:5. doi: 10.1186/1472-6807-13-5. PMID:23617613 doi:10.1186/1472-6807-13-5

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