4lts

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'''Unreleased structure'''
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{{STRUCTURE_4lts| PDB=4lts | SCENE= }}
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===Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors===
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{{ABSTRACT_PUBMED_24279990}}
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The entry 4lts is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN]] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).
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Authors: Zheng, X., Baumeister, T., Buckmelter, A.J., Caligiuri, M., Clodfelter, K.H., Han, B., Ho, Y., Kley, N., Lin, J., Reynoids, D.J., Sharma, G., Smith, C.C., Wang, Z., Dragovich, P.S., Oh, A., Wang, W., Zak, M., Wang, Y., Yuen, P., Bair, K.W.
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==About this Structure==
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[[4lts]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LTS OCA].
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Description: Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors
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==Reference==
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<ref group="xtra">PMID:024279990</ref><references group="xtra"/><references/>
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[[Category: Nicotinamide phosphoribosyltransferase]]
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[[Category: Bair, K W.]]
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[[Category: Baumeister, T.]]
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[[Category: Buckmelter, A J.]]
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[[Category: Caligiuri, M.]]
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[[Category: Clodfelter, K H.]]
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[[Category: Dragovich, P S.]]
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[[Category: Han, B.]]
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[[Category: Ho, Y.]]
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[[Category: Kley, N.]]
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[[Category: Lin, J.]]
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[[Category: Oh, A.]]
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[[Category: Reynoids, D J.]]
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[[Category: Sharma, G.]]
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[[Category: Smith, C C.]]
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[[Category: Wang, L]]
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[[Category: Wang, W.]]
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[[Category: Wang, Z.]]
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[[Category: Yuen, P.]]
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[[Category: Zak, M.]]
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[[Category: Zheng, X.]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]

Revision as of 10:11, 25 December 2013

Template:STRUCTURE 4lts

Contents

Discovery of Potent and Efficacious Cyanoguanidine-containing Nicotinamide Phosphoribosyltransferase (Nampt) Inhibitors

Template:ABSTRACT PUBMED 24279990

Function

[NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity).

About this Structure

4lts is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Zheng X, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Han B, Ho YC, Kley N, Lin J, Reynolds DJ, Sharma G, Smith CC, Wang Z, Dragovich PS, Oh A, Wang W, Zak M, Wang Y, Yuen PW, Bair KW. Discovery of potent and efficacious cyanoguanidine-containing nicotinamide phosphoribosyltransferase (Nampt) inhibitors. Bioorg Med Chem Lett. 2013 Nov 14. pii: S0960-894X(13)01285-7. doi:, 10.1016/j.bmcl.2013.11.006. PMID:24279990 doi:http://dx.doi.org/10.1016/j.bmcl.2013.11.006

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OCA

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