4bx3

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'''Unreleased structure'''
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{{STRUCTURE_4bx3| PDB=4bx3 | SCENE= }}
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===Crystal Structure of murine Chronophin (Pyridoxal Phosphate Phosphatase)===
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{{ABSTRACT_PUBMED_24338687}}
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The entry 4bx3 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/PLPP_MOUSE PLPP_MOUSE]] Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP (By similarity).
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Authors: Knobloch, G., Gohla, A., Schindelin, H.
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==About this Structure==
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[[4bx3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BX3 OCA].
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Description: Crystal Structure of murine Chronophin (Pyridoxal Phosphate Phosphatase)
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==Reference==
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<ref group="xtra">PMID:024338687</ref><references group="xtra"/><references/>
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[[Category: Gohla, A.]]
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[[Category: Knobloch, G.]]
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[[Category: Schindelin, H.]]
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[[Category: Had phosphatase]]
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[[Category: Had-like hydrolase]]
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[[Category: Hydrolase]]
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[[Category: Pdxp]]

Revision as of 10:16, 25 December 2013

Template:STRUCTURE 4bx3

Contents

Crystal Structure of murine Chronophin (Pyridoxal Phosphate Phosphatase)

Template:ABSTRACT PUBMED 24338687

Function

[PLPP_MOUSE] Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP (By similarity).

About this Structure

4bx3 is a 2 chain structure. Full crystallographic information is available from OCA.

Reference

  • Kestler C, Knobloch G, Tessmer I, Jeanclos E, Schindelin H, Gohla A. Chronophin dimerization is required for proper positioning of its substrate specificity loop. J Biol Chem. 2013 Dec 14. PMID:24338687 doi:http://dx.doi.org/10.1074/jbc.M113.536482

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OCA

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