4lh6

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'''Unreleased structure'''
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{{STRUCTURE_4lh6| PDB=4lh6 | SCENE= }}
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===Crystal structure of a LigA inhibitor===
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{{ABSTRACT_PUBMED_24287382}}
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The entry 4lh6 is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/DNLJ_ENTFA DNLJ_ENTFA]] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).
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Authors: Benenato, K., Wang, H., Mcguire, H.M., Davis, H., Gao, N., Prince, D.B., Jahic, H., Stokes, S.S., Boriack-Sjodin, P.A.
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==About this Structure==
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[[4lh6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LH6 OCA].
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Description: Crystal structure of a LigA inhibitor
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==Reference==
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<ref group="xtra">PMID:024287382</ref><references group="xtra"/><references/>
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[[Category: Benenato, K.]]
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[[Category: Boriack-Sjodin, P A.]]
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[[Category: Davis, H.]]
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[[Category: Gao, N.]]
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[[Category: Jahic, H.]]
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[[Category: Mcguire, H M.]]
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[[Category: Prince, D B.]]
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[[Category: Stokes, S S.]]
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[[Category: Wang, H.]]
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[[Category: Ligase-ligase inhibitor complex]]
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[[Category: Protein-inhibitor complex]]

Revision as of 10:19, 25 December 2013

Template:STRUCTURE 4lh6

Contents

Crystal structure of a LigA inhibitor

Template:ABSTRACT PUBMED 24287382

Function

[DNLJ_ENTFA] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).

About this Structure

4lh6 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Murphy-Benenato K, Wang H, McGuire HM, Davis HE, Gao N, Prince DB, Jahic H, Stokes SS, Boriack-Sjodin PA. Identification through structure-based methods of a bacterial NAD-dependent DNA ligase inhibitor that avoids known resistance mutations. Bioorg Med Chem Lett. 2013 Nov 15. pii: S0960-894X(13)01286-9. doi:, 10.1016/j.bmcl.2013.11.007. PMID:24287382 doi:http://dx.doi.org/10.1016/j.bmcl.2013.11.007

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OCA

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