4id4
From Proteopedia
(Difference between revisions)
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| - | + | {{STRUCTURE_4id4| PDB=4id4 | SCENE= }} | |
| + | ===Crystal structure of chimeric beta-lactamase cTEM-17m=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/BLAT_ECOLX BLAT_ECOLX]] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors. | ||
| - | + | ==About this Structure== | |
| - | + | [[4id4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ID4 OCA]. | |
| - | + | [[Category: Beta-lactamase]] | |
| + | [[Category: Berghuis, A M.]] | ||
| + | [[Category: Gobeil, S.]] | ||
| + | [[Category: Park, J.]] | ||
| + | [[Category: Pelletier, J N.]] | ||
| + | [[Category: Beta-lactamase]] | ||
| + | [[Category: Hydrolase]] | ||
Revision as of 10:24, 25 December 2013
Crystal structure of chimeric beta-lactamase cTEM-17m
Function
[BLAT_ECOLX] TEM-type are the most prevalent beta-lactamases in enterobacteria; they hydrolyze the beta-lactam bond in susceptible beta-lactam antibiotics, thus conferring resistance to penicillins and cephalosporins. TEM-3 and TEM-4 are capable of hydrolyzing cefotaxime and ceftazidime. TEM-5 is capable of hydrolyzing ceftazidime. TEM-6 is capable of hydrolyzing ceftazidime and aztreonam. TEM-8/CAZ-2, TEM-16/CAZ-7 and TEM-24/CAZ-6 are markedly active against ceftazidime. IRT-4 shows resistance to beta-lactamase inhibitors.
About this Structure
4id4 is a 1 chain structure. Full crystallographic information is available from OCA.
