4iio

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'''Unreleased structure'''
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{{STRUCTURE_4iio| PDB=4iio | SCENE= }}
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===Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide===
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The entry 4iio is ON HOLD until Dec 20 2014
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==Function==
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[[http://www.uniprot.org/uniprot/ITSN2_HUMAN ITSN2_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).<ref>PMID:19458185</ref> <ref>PMID:22648170</ref>
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Authors: Dong, A., Guan, X., Huang, H., Gu, J., Tempel, W., Sidhu, S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
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==About this Structure==
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[[4iio]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIO OCA].
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Description: Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Dong, A.]]
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[[Category: Edwards, A M.]]
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[[Category: Gu, J.]]
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[[Category: Guan, X.]]
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[[Category: Huang, H.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sidhu, S.]]
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[[Category: Tempel, W.]]
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[[Category: Tong, Y.]]
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[[Category: Endocytosis]]
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[[Category: Itsn2]]
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[[Category: Protein-peptide complex]]
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[[Category: Sgc]]
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[[Category: Sh3 domain]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Synthetic peptide]]

Revision as of 10:25, 25 December 2013

Template:STRUCTURE 4iio

Contents

Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide

Function

[ITSN2_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).[1] [2]

About this Structure

4iio is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  1. Mettlen M, Stoeber M, Loerke D, Antonescu CN, Danuser G, Schmid SL. Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. Mol Biol Cell. 2009 Jul;20(14):3251-60. doi: 10.1091/mbc.E09-03-0256. Epub 2009, May 20. PMID:19458185 doi:10.1091/mbc.E09-03-0256
  2. Teckchandani A, Mulkearns EE, Randolph TW, Toida N, Cooper JA. The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis. Mol Biol Cell. 2012 Aug;23(15):2905-16. doi: 10.1091/mbc.E11-12-1007. Epub 2012, May 30. PMID:22648170 doi:10.1091/mbc.E11-12-1007

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