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4iio

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4iio| PDB=4iio | SCENE= }}
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===Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide===
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The entry 4iio is ON HOLD until Dec 20 2014
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==Function==
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[[http://www.uniprot.org/uniprot/ITSN2_HUMAN ITSN2_HUMAN]] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).<ref>PMID:19458185</ref> <ref>PMID:22648170</ref>
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Authors: Dong, A., Guan, X., Huang, H., Gu, J., Tempel, W., Sidhu, S., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
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==About this Structure==
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[[4iio]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIO OCA].
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Description: Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Arrowsmith, C H.]]
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[[Category: Bountra, C.]]
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[[Category: Dong, A.]]
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[[Category: Edwards, A M.]]
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[[Category: Gu, J.]]
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[[Category: Guan, X.]]
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[[Category: Huang, H.]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sidhu, S.]]
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[[Category: Tempel, W.]]
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[[Category: Tong, Y.]]
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[[Category: Endocytosis]]
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[[Category: Itsn2]]
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[[Category: Protein-peptide complex]]
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[[Category: Sgc]]
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[[Category: Sh3 domain]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Synthetic peptide]]

Revision as of 10:25, 25 December 2013

Template:STRUCTURE 4iio

Contents

Crystal Structure of the Second SH3 Domain of ITSN2 Bound with a Synthetic Peptide

Function

[ITSN2_HUMAN] Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR).[1] [2]

About this Structure

4iio is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Mettlen M, Stoeber M, Loerke D, Antonescu CN, Danuser G, Schmid SL. Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. Mol Biol Cell. 2009 Jul;20(14):3251-60. doi: 10.1091/mbc.E09-03-0256. Epub 2009, May 20. PMID:19458185 doi:10.1091/mbc.E09-03-0256
  2. ↑ Teckchandani A, Mulkearns EE, Randolph TW, Toida N, Cooper JA. The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis. Mol Biol Cell. 2012 Aug;23(15):2905-16. doi: 10.1091/mbc.E11-12-1007. Epub 2012, May 30. PMID:22648170 doi:10.1091/mbc.E11-12-1007

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