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4keh

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'''Unreleased structure'''
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{{STRUCTURE_4keh| PDB=4keh | SCENE= }}
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===Crosslinked Crystal Structure of Type II Fatty Synthase Dehydratase, FabA, and Acyl Carrier Protein, AcpP===
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The entry 4keh is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/FABA_ECOLI FABA_ECOLI]] Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. Is inactive in the dehydration of long chain unsaturated beta-hydroxyacyl-ACP.<ref>PMID:8910376</ref> [[http://www.uniprot.org/uniprot/K0BL73_ECO1E K0BL73_ECO1E]] Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity).[RuleBase:RU003545][HAMAP-Rule:MF_01217]
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Authors: Nguyen, C., Haushalter, R., Finzel, K., Leong, J., Le, B.C., Burkart, M., Tsai, S.C.
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==About this Structure==
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[[4keh]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KEH OCA].
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Description: Crosslinked Crystal Structure of Type II Fatty Synthase Dehydratase, FabA, and Acyl Carrier Protein, AcpP
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==Reference==
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<references group="xtra"/><references/>
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[[Category: Burkart, M.]]
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[[Category: Finzel, K.]]
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[[Category: Haushalter, R.]]
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[[Category: Le, B C.]]
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[[Category: Leong, J.]]
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[[Category: Nguyen, C.]]
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[[Category: Tsai, S C.]]
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[[Category: Acyl carrier protein]]
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[[Category: Dehydratase/isomerase]]
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[[Category: Fatty acid synthesis]]
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[[Category: Isomerase-biosynthetic protein complex]]
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[[Category: Protein-protein complex]]

Revision as of 10:26, 25 December 2013

Template:STRUCTURE 4keh

Contents

Crosslinked Crystal Structure of Type II Fatty Synthase Dehydratase, FabA, and Acyl Carrier Protein, AcpP

Function

[FABA_ECOLI] Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. Is inactive in the dehydration of long chain unsaturated beta-hydroxyacyl-ACP.[1] [K0BL73_ECO1E] Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity).[RuleBase:RU003545][HAMAP-Rule:MF_01217]

About this Structure

4keh is a 4 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Heath RJ, Rock CO. Roles of the FabA and FabZ beta-hydroxyacyl-acyl carrier protein dehydratases in Escherichia coli fatty acid biosynthesis. J Biol Chem. 1996 Nov 1;271(44):27795-801. PMID:8910376

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