4lez
From Proteopedia
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| - | + | {{STRUCTURE_4lez| PDB=4lez | SCENE= }} | |
| + | ===Structure of mouse cGAS bound to an 18bp DNA and cGAS product=== | ||
| - | + | ==Function== | |
| + | [[http://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. | ||
| - | + | ==About this Structure== | |
| - | + | [[4lez]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEZ OCA]. | |
| - | + | [[Category: Li, P.]] | |
| + | [[Category: Dna sensor]] | ||
| + | [[Category: Ntase]] | ||
| + | [[Category: Transferase-dna complex]] | ||
Revision as of 10:27, 25 December 2013
Structure of mouse cGAS bound to an 18bp DNA and cGAS product
Function
[CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
About this Structure
4lez is a 6 chain structure. Full crystallographic information is available from OCA.
