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4lez

From Proteopedia

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'''Unreleased structure'''
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{{STRUCTURE_4lez| PDB=4lez | SCENE= }}
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===Structure of mouse cGAS bound to an 18bp DNA and cGAS product===
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The entry 4lez is ON HOLD until Paper Publication
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==Function==
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[[http://www.uniprot.org/uniprot/CGAS_MOUSE CGAS_MOUSE]] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.
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Authors: Li, P.
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==About this Structure==
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[[4lez]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LEZ OCA].
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Description: Structure of mouse cGAS bound to an 18bp DNA and cGAS product
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[[Category: Li, P.]]
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[[Category: Dna sensor]]
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[[Category: Ntase]]
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[[Category: Transferase-dna complex]]

Revision as of 10:27, 25 December 2013

Template:STRUCTURE 4lez

Structure of mouse cGAS bound to an 18bp DNA and cGAS product

Function

[CGAS_MOUSE] Nucleotidyltransferase that catalyzes formation of cyclic GMP-AMP (cGAMP) from ATP and GTP and exhibits antiviral activity. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of DNA in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production.

About this Structure

4lez is a 6 chain structure. Full crystallographic information is available from OCA.

Proteopedia Page Contributors and Editors (what is this?)

OCA

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