4lqk

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'''Unreleased structure'''
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{{STRUCTURE_4lqk| PDB=4lqk | SCENE= }}
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===Structure of the vaccinia virus NF- B antagonist A46===
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The entry 4lqk is ON HOLD
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==Function==
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[[http://www.uniprot.org/uniprot/A46_VACCW A46_VACCW]] Bcl-2-like protein which disrupts the host immune response by inhibiting the TLR4 signaling pathway leading to NF-kappa-B activation. Targets several host TIR adapters including MYD88, TIRAP, TRIF and TICAM2 thereby blocking NF-kappa-B and TRIF-mediated IRF3 activation.
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Authors: Grishkovskaya, I., Fedosyuk, S., Skern, T., Djinovic-Carugo, K.
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==About this Structure==
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[[4lqk]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LQK OCA].
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Description: Structure of the vaccinia virus NF-B antagonist A46
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[[Category: Djinovic-Carugo, K.]]
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[[Category: Fedosyuk, S.]]
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[[Category: Grishkovskaya, I.]]
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[[Category: Skern, T.]]
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[[Category: Bcl-2-like fold]]
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[[Category: Viral protein]]

Revision as of 10:27, 25 December 2013

Template:STRUCTURE 4lqk

Structure of the vaccinia virus NF- B antagonist A46

Function

[A46_VACCW] Bcl-2-like protein which disrupts the host immune response by inhibiting the TLR4 signaling pathway leading to NF-kappa-B activation. Targets several host TIR adapters including MYD88, TIRAP, TRIF and TICAM2 thereby blocking NF-kappa-B and TRIF-mediated IRF3 activation.

About this Structure

4lqk is a 4 chain structure. Full crystallographic information is available from OCA.

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OCA

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